Evidence map›Paper›PMID 26905950›Full record

ReviewNeuroscience2017

Developmental changes in serotonin signaling: Implications for early brain function, behavior and adaptation.

S Brummelte, E Mc Glanaghy, A Bonnin, T F Oberlander

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed, 3 pooled it
32.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

142 citing papers in PubMed, 3 syntheses or guidelines pooled it, 301 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Association of prenatal antidepressant use with internalizing behaviors from kindergarten to adolescence.Journal of child psychology and psychiatry, and allied disciplines · 2026
    Article
  17. Article
  18. Review
  19. Review
  20. Review

82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

S BrummelteDepartment of Psychology, Wayne State University, 5057 Woodward Avenue, Detroit, MI 48202, USA. Electronic address: sbrummelte@wayne.edu.
E Mc GlanaghyDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada; Child & Family Research Institute, University of British Columbia, Vancouver, BC, Canada.
A BonninZilkha Neurogenetic Institute and Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
T F OberlanderDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada; Child & Family Research Institute, University of British Columbia, Vancouver, BC, Canada.
University of British Columbia · CAUniversity of Southern California · USWayne State University · US

Funding

Prenatal stress and antidepressants effects on offspring brain developmentR01MH106806 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BONNIN, ALEXANDRE · 2016 to 2020
$2.1M
CIHRNIMH NIH HHS R01 MH106806
6 · The paper itself

Abstract

The neurotransmitter serotonin (5-HT) plays a central role in brain development, regulation of mood, stress reactivity and risk of psychiatric disorders, and thus alterations in 5-HT signaling early in life have critical implications for behavior and mental health across the life span. Drawing on preclinical and emerging human evidence this narrative review paper will examine three key aspects when considering the consequences of early life changes in 5-HT: (1) developmental origins of variations of 5-HT signaling; (2) influence of genetic and epigenetic factors; and (3) preclinical and clinical consequences of 5-HT-related changes associated with antidepressant exposure (SSRIs). The developmental consequences of altered prenatal 5-HT signaling varies greatly and outcomes depend on an ongoing interplay between biological (genetic/epigenetic variations) and environmental factors, both pre and postnatally. Emerging evidence suggests that variations in 5-HT signaling may increase sensitivity to risky home environments, but may also amplify a positive response to a nurturing environment. In this sense, factors that change central 5-HT levels may act as 'plasticity' rather than 'risk' factors associated with developmental vulnerability. Understanding the impact of early changes in 5-HT levels offers critical insights that might explain the variations in early typical brain development that underlies behavioral risk.

Indexed as

AnimalsBrainHumansSerotoninSignal TransductionSerotonin5-HTepigeneticsfetal developmentmaternal depressionneurodevelopmentSSRI exposure

Identifiers

PMID26905950
PMCPMC5310545
OpenAlexW2284801858

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.