ArticleEuropean radiology2016
In vivo dentate nucleus MRI relaxometry correlates with previous administration of Gadolinium-based contrast agents.
Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Detailed Mapping of the Cerebellar Dentate Nucleus Using Ultra-High Field (7T) Susceptibility-Weighted Imaging.Cerebellum (London, England) · 2025Article
- Gadolinium Contrast Agent Deposition in Children.Journal of magnetic resonance imaging : JMRI · 2025Review
- Ten years of gadolinium retention and deposition: ESMRMB-GREC looks backward and forward.European radiology · 2024Review
- Prospective T1 mapping to assess gadolinium retention in brain after intrathecal gadobutrol.Neuroradiology · 2023Article
- Brain deposition of gadobutrol in children-a cross-sectional and longitudinal MRI T1 mapping study.European radiology · 2023Article
- MR Imaging Signs of Gadolinium Retention Are Not Associated with Long-Term Motor and Cognitive Outcomes in Multiple Sclerosis.AJNR. American journal of neuroradiology · 2023Article
- The benefits and side effects of gadolinium-based contrast agents in multiple sclerosis patients.Revista da Associacao Medica Brasileira (1992) · 2022Article
- Dentate-nucleus gadolinium deposition on magnetic resonance imaging: ultrasonographic and clinical correlates in multiple sclerosis patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Walk Your Talk: Real-World Adherence to Guidelines on the Use of MRI in Multiple Sclerosis.Diagnostics (Basel, Switzerland) · 2021Article
- Unraveling Deep Gray Matter Atrophy and Iron and Myelin Changes in Multiple Sclerosis.AJNR. American journal of neuroradiology · 2021Article
- MRI and muscle imaging for idiopathic inflammatory myopathies.Brain pathology (Zurich, Switzerland) · 2021Review
- Detection of gadolinium deposition in cortical bone with ultrashort echo time TEuropean radiology · 2021Article
- Gadolinium deposition in the brain of dogs after multiple intravenous administrations of linear gadolinium based contrast agents.PloS one · 2020Article
- Cumulative gadodiamide administration leads to brain gadolinium deposition in early MS.Neurology · 2019Article
- Signal Hyperintensity on Unenhanced T1-Weighted Brain and Cervical Spinal Cord MR Images after Multiple Doses of Linear Gadolinium-Based Contrast Agent.AJNR. American journal of neuroradiology · 2019Article
- Gadolinium Retention in the Brain: An MRI Relaxometry Study of Linear and Macrocyclic Gadolinium-Based Contrast Agents in Multiple Sclerosis.AJNR. American journal of neuroradiology · 2019Article
- Standardized assessment of the signal intensity increase on unenhanced T1-weighted images in the brain: the European Gadolinium Retention Evaluation Consortium (GREC) Task Force position statement.European radiology · 2019Review
- MRI features suggestive of gadolinium retention do not correlate with Expanded Disability Status Scale worsening in Multiple Sclerosis.Neuroradiology · 2019Article
- Determinants of Deep Gray Matter Atrophy in Multiple Sclerosis: A Multimodal MRI Study.AJNR. American journal of neuroradiology · 2019Article
Corrections and comments
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Authors and funding
13 authors.
Funding
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Abstract
objectivesTo evaluate changes in T1 and T2* relaxometry of dentate nuclei (DN) with respect to the number of previous administrations of Gadolinium-based contrast agents (GBCA).
methodsIn 74 relapsing-remitting multiple sclerosis (RR-MS) patients with variable disease duration (9.8±6.8 years) and severity (Expanded Disability Status Scale scores:3.1±0.9), the DN R1 (1/T1) and R2* (1/T2*) relaxation rates were measured using two unenhanced 3D Dual-Echo spoiled Gradient-Echo sequences with different flip angles. Correlations of the number of previous GBCA administrations with DN R1 and R2* relaxation rates were tested, including gender and age effect, in a multivariate regression analysis.
resultsThe DN R1 (normalized by brainstem) significantly correlated with the number of GBCA administrations (p<0.001), maintaining the same significance even when including MS-related factors. Instead, the DN R2* values correlated only with age (p=0.003), and not with GBCA administrations (p=0.67). In a subgroup of 35 patients for whom the administered GBCA subtype was known, the effect of GBCA on DN R1 appeared mainly related to linear GBCA.
conclusionsIn RR-MS patients, the number of previous GBCA administrations correlates with R1 relaxation rates of DN, while R2* values remain unaffected, suggesting that T1-shortening in these patients is related to the amount of Gadolinium given. KEY POINTS: • In multiple sclerosis, previous Gadolinium administrations correlate with dentate nuclei T1 relaxometry. • Such correlation is linked to linear Gadolinium chelates and unrelated to disease duration or severity. • Dentate nuclei T2* relaxometry is age-related and independent of previous Gadolinium administrations. • Changes in dentate nuclei T1 relaxometry are not determined by iron accumulation. • MR relaxometry can quantitatively assess Gadolinium accumulation in dentate nuclei.
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