ArticleAmerican journal of infection control2016
Intestinal microbiome disruption in patients in a long-term acute care hospital: A case for development of microbiome disruption indices to improve infection prevention.
Article in American journal of infection control, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Repeated rectal application of a hyperosmolar lubricant is associated with microbiota shifts but does not affect PrEP drug concentrations: results from a randomized trial in men who have sex with men.Journal of the International AIDS Society · 2018Trial
- Isolation and characterization of an antibiofilm bacteriophage against Klebsiella michiganensis and evaluation of its therapeutic potential in an insect larval gut colonization model.BMC microbiology · 2025Article
- Gut microbiota dysbiosis and systemic immune dysfunction in critical ill patients with multidrug-resistant bacterial colonization and infection.Journal of translational medicine · 2025Article
- Bacteriophage-mediated decolonization of Klebsiella pneumoniae in a novel Galleria mellonella gut colonization model with Enterobacteriaceae.Scientific reports · 2024Article
- Antibiotics Drive Expansion of Rare Pathogens in a Chronic Infection Microbiome Model.mSphere · 2022Article
- Longitudinal Dynamics of Skin Bacterial Communities in the Context of Staphylococcus aureus Decolonization.Microbiology spectrum · 2022Article
- Framing Bacterial Genomics for Public Health (Care).Journal of clinical microbiology · 2021Article
- Changes in gut microbiota in the acute phase after spinal cord injury correlate with severity of the lesion.Scientific reports · 2021Article
- Current Capabilities of Gut Microbiome-Based Diagnostics and the Promise of Clinical Application.The Journal of infectious diseases · 2021Review
- Association between Clostridioides difficile infection and multidrug-resistant organism colonization or infection among hospitalized adults: A case-control study.American journal of infection control · 2020Article
- Protection of gut microbiome from antibiotics: development of a vancomycin-specific adsorbent with high adsorption capacity.Bioscience of microbiota, food and health · 2020Article
- Epidemiological and Microbiome Associations BetweenOpen forum infectious diseases · 2020Article
- The Role of Fecal Microbiota Transplantation in Reducing Intestinal Colonization With Antibiotic-Resistant Organisms: The Current Landscape and Future Directions.Open forum infectious diseases · 2019Article
- Increased Relative Abundance of Klebsiella pneumoniae Carbapenemase-producing Klebsiella pneumoniae Within the Gut Microbiota Is Associated With Risk of Bloodstream Infection in Long-term Acute Care Hospital Patients.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Microbiome predictors of dysbiosis and VRE decolonization in patients with recurrentAIMS microbiology · 2019Article
- Chrononutrition Applied to Diabetes Management: A Paradigm Shift Long Delayed.Diabetes spectrum : a publication of the American Diabetes Association · 2018Article
- Gut Microbiota and Clinical Features Distinguish Colonization WithOpen forum infectious diseases · 2018Article
- Considering the Potential Application of Whole Genome Sequencing to Gonorrhea Prevention and Control.Sexually transmitted diseases · 2018Article
- Microbial Disruption Indices to Detect Colonization With Multidrug-Resistant Organisms.Infection control and hospital epidemiology · 2017Article
- The rectal mucosa and condomless receptive anal intercourse in HIV-negative MSM: implications for HIV transmission and prevention.Mucosal immunology · 2017Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundComposition and diversity of intestinal microbial communities (microbiota) are generally accepted as a risk factor for poor outcomes; however, we cannot yet use this information to prevent adverse outcomes.
methodsStool was collected from 8 long-term acute care hospital patients experiencing diarrhea and 2 fecal microbiota transplant donors; 16S rDNA V1-V2 hypervariable regions were sequenced. Composition and diversity of each sample were described. Stool was also tested for Clostridium difficile, vancomycin-resistant enterococci (VRE), and carbapenem-resistant Enterobacteriaceae. Associations between microbiota diversity and demographic and clinical characteristics, including antibiotic use, were analyzed.
resultsAntibiotic exposure and Charlson Comorbidity Index were inversely correlated with diversity (Spearman = -0.7). Two patients were positive for VRE; both had microbiomes dominated by Enterococcus faecium, accounting for 67%-84% of their microbiome.
conclusionsAntibiotic exposure correlated with diversity; however, other environmental and host factors not easily obtainable in a clinical setting are also known to impact the microbiota. Therefore, direct measurement of microbiome disruption by sequencing, rather than reliance on surrogate markers, might be most predictive of adverse outcomes. If and when microbiome characterization becomes a standard diagnostic test, improving our understanding of microbiome dynamics will allow for interpretation of results to improve patient outcomes.
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