ArticleBMC infectious diseases2016
Isolation and identification of Candida species in patients with orogastric cancer: susceptibility to antifungal drugs, attributes of virulence in vitro and immune response phenotype.
Article in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 29 citations in OpenAlex.
- Clinical Isolate ofOpen journal of medical microbiology · 2025Article
- What IsMicroorganisms · 2022Review
- Multilocus Sequence Typing and Antifungal Susceptibility ofFrontiers in veterinary science · 2022Article
- Interactions betweenFrontiers in microbiology · 2022Review
- Evaluation of the phytoconstituents ofEuropean journal of integrative medicine · 2020Article
- Does microbiome shift play a role in carcinogenesis? A systematic review.Translational cancer research · 2020Review
- Investigating cross-contamination by yeast strains from dental solid waste to waste-handling workers by DNA sequencing.MicrobiologyOpen · 2018Article
- Identification of uncommon oral yeasts from cancer patients by MALDI-TOF mass spectrometry.BMC infectious diseases · 2018Article
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Authors and funding
14 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBecause of the inherent immunosuppression of cancer patients opportunistic infections by Candida spp, occur frequently. This study aimed to identify Candida species in the oral mucosa of 59 patients with orogastric cancer (OGC) and to analyze the immunological phenotype of these patients.
methodsThe yeasts were identified by MALDI-TOF mass spectrometry (MS). For all isolates, we performed phospholipases and proteinases assays, in vitro adherence to buccal epithelial cells (BEC), minimum inhibitory concentration of antifungal drugs and determined the cytokine profile by Cytometric Bead Array flow citometry assay.
resultsC. albicans was the most prevalent species in OGC patients (51.6 %) and control group (66.7 %). Candida spp. strains isolated from OGC patients exhibited better adherence to BEC (p = 0.05) than did the control group. Phospholipases production by Candida strains from OGC patients was lower (51.6 %) than in the control group (61.9 %). Proteinases were detected in 41.9 % and 4.8 % of the yeasts from OGC patients and control group, respectively. Significant differences were found in the serum of OGC patients compared to the control group for IL-2, IL-10, TNF-α, IFN-γ and IL-17.
conclusionsThe results of this work suggest increased virulence of yeasts isolated from OGC patients and, that this may interfere with the immune phenotype.
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