ArticleScientific reports2016
Antithrombotic and antiplatelet activities of small-molecule alkaloids from Scolopendra subspinipes mutilans.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- Recent advances in progress of natural anticoagulant active substances.Journal of natural medicines · 2026Review
- Mechanisms and research progress of insect-derived medicines in intervention for ischemic stroke.IBRO neuroscience reports · 2025Review
- Therapeutic Potential ofToxins · 2025Article
- A novel class of indole derivatives: enhanced bioavailability, permeability, and antioxidant efficacy for thromboembolic disease therapy.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2024Article
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- Rodent models of pulmonary embolism and chronic thromboembolic pulmonary hypertension.Heliyon · 2022Review
- Anti-thrombotic activity of phenolic acids obtained from Salvia miltiorrhiza f. alba in TNF-α-stimulated endothelial cells via the NF-κB/JNK/p38 MAPK signaling pathway.Archives of pharmacal research · 2021Article
- Toxic Animal-Based Medicinal Materials Can Be Effective in Treating Endometriosis: A Scoping Review.Toxins · 2021Article
- Article
- Anti-Thrombotic, Anti-Oxidant and Haemolysis Activities of Six Edible Insect Species.Foods (Basel, Switzerland) · 2020Article
- A Review of Antiplatelet Activity of Traditional Medicinal Herbs on Integrative Medicine Studies.Evidence-based complementary and alternative medicine : eCAM · 2019Review
- Biologically active quinoline and quinazoline alkaloids part II.Medicinal research reviews · 2018Review
- Medicinal plants with antithrombotic property in Persian medicine: a mechanistic review.Journal of thrombosis and thrombolysis · 2018Review
- Refinement of Mouse Protocols for the Study of Platelet Thromboembolic Responses In Vivo.Thrombosis and haemostasis · 2017Article
- Inhibition of platelet aggregation and thrombosis by indole alkaloids isolated from the edible insect Protaetia brevitarsis seulensis (Kolbe).Journal of cellular and molecular medicine · 2017Article
- Inhibition of melanogenesis by jineol from Scolopendra subspinipes mutilans via MAP-Kinase mediated MITF downregulation and the proteasomal degradation of tyrosinase.Scientific reports · 2017Article
- Antibacterial Action of Jineol Isolated fromFrontiers in microbiology · 2017Article
- Plant Alkaloids as Antiplatelet Agent: Drugs of the Future in the Light of Recent Developments.Frontiers in pharmacology · 2016Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to discover small-molecule anticoagulants from Scolopendra subspinipes mutilans (SSM). A new acylated polyamine (1) and a new sulfated quinoline alkaloid (2) were isolated from SSM. Treatment with the new alkaloids 1, 2, and indole acetic acid 4 prolonged the activated partial thromboplastin time and prothrombin time and inhibited the activity and production of thrombin and activated factor X. Furthermore, compounds 1, 2, and 4 inhibited thrombin-catalyzed fibrin polymerization and platelet aggregation. In accordance with these potential in vitro antiplatelet activities, compounds 1, 2, and 4 showed enhanced antithrombotic effects in an in vivo pulmonary embolism and arterial thrombosis model. Compounds 1, 2, and 4 also elicited anticoagulant effects in mice. Collectively, this study may serve as the groundwork for commercializing SSM or compounds 1, 2, and 4 as functional food components for the prevention and treatment of pathogenic conditions and serve as new scaffolds for the development of anticoagulants.
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