ArticleTranslational psychiatry2016
Oxidative stress, anti-oxidants and the cross-sectional and longitudinal association with depressive symptoms: results from the CARDIA study.
Article in Translational psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Classifying oxidative stress by FRedox biology · 2017Pooled it
- Associations of dietary and plasma lutein + zeaxanthin with depression in US adults: findings from NHANES.Asia Pacific journal of clinical nutrition · 2025Article
- Association between consumption of fruits and vegetables in midlife and depressive symptoms in late life: the Singapore Chinese Health Study.The journal of nutrition, health & aging · 2024Article
- Curcumin Derivatives Linked to a Reduction of Oxidative Stress in Mental Dysfunctions and Inflammatory Disorders.Current medicinal chemistry · 2024Review
- Antioxidant and Anti-Inflammatory Effects of Carotenoids in Mood Disorders: An Overview.Antioxidants (Basel, Switzerland) · 2023Review
- Dissecting Causal Associations of Diet-Derived Circulating Antioxidants with Six Major Mental Disorders: A Mendelian Randomization Study.Antioxidants (Basel, Switzerland) · 2023Article
- The emergence of psychoanalytical electrochemistry: the translation of MDD biomarker discovery to diagnosis with electrochemical sensing.Translational psychiatry · 2022Review
- Association of dietary and plasma carotenoids with urinary FEuropean journal of nutrition · 2022Article
- Metformin alleviates monoamine oxidase-related vascular oxidative stress and endothelial dysfunction in rats with diet-induced obesity.Molecular and cellular biochemistry · 2021Article
- Association of habitual intake of fruits and vegetables with depressive symptoms: the AusDiab study.European journal of nutrition · 2021Article
- Nutrient patterns and depressive symptoms among Australian adults.European journal of nutrition · 2021Article
- The association between antioxidant intake, dietary pattern and depressive symptoms in older Australian men: the Concord Health and Ageing in Men Project.European journal of nutrition · 2021Article
- Non-alcoholic fatty liver disease (NAFLD) as a neglected metabolic companion of psychiatric disorders: common pathways and future approaches.BMC medicine · 2020Review
- The Effect of Lycopene Supplementation on Mood Status and Quality of Life in Infertile Men: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.International journal of fertility & sterility · 2020Article
- Evaluating Longitudinal Associations Between Depressive Symptoms, Smoking, and Biomarkers of Cardiovascular Disease in the CARDIA Study.Psychosomatic medicine · 2019Article
- Fruit and vegetable consumption is associated with improved mental and cognitive health in older adults from non-Western developing countries.Public health nutrition · 2019Article
- Behavioral defects induced by chronic social defeat stress are protected byAnnals of translational medicine · 2019Article
- Zeaxanthin improved diabetes-induced anxiety and depression through inhibiting inflammation in hippocampus.Metabolic brain disease · 2018Article
- Oxidative stress in drug-naïve first episode patients with schizophrenia and major depression: effects of disease acuity and potential confounders.European archives of psychiatry and clinical neuroscience · 2018Article
- Fruits and vegetables intake and its subgroups are related to depression: a cross-sectional study from a developing country.Annals of general psychiatry · 2018Article
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Depression may be accompanied by increased oxidative stress and decreased circulating anti-oxidants. This study examines the association between depressive symptoms, F2-isoprostanes and carotenoids in a US community sample. The study includes 3009 participants (mean age 40.3, 54.2% female) from CARDIA (Coronary Artery Risk Development in Young Adults). Cross-sectional analyses were performed on data from the year 15 examination (2000-2001) including subjects whose depressive symptoms were assessed with the Center for Epidemiologic Studies Depression Scale (CES-D) and had measurements of plasma F2-isoprostanes (gas chromatography/mass spectrometry) or serum carotenoids (high-performance liquid chromatography). Carotenoids zeaxanthin/lutein, β-cryptoxanthin, lycopene, α-carotene, β-carotene were standardized and summed. Longitudinal analyses were conducted using the data from other examinations at 5-year intervals. Cross-lagged analyses investigated whether CES-D predicted F2-isoprostanes or carotenoids at the following exam, and vice versa. Regression analyses were controlled for sociodemographics, health and lifestyle factors. F2-isoprostanes were higher in subjects with depressive symptoms (CES-D ⩾ 16) after adjustment for sociodemographics (55.7 vs 52.0 pg ml(-1); Cohen's d = 0.14, P < 0.001). There was no difference in F2-isoprostanes after further adjustment for health and lifestyle factors. Carotenoids were lower in those with CES-D scores ⩾ 16, even after adjustment for health and lifestyle factors (standardized sum 238.7 vs 244.0, Cohen's d = -0.16, P < 0.001). Longitudinal analyses confirmed that depression predicts subsequent F2-isoprostane and carotenoid levels. Neither F2-isoprostanes nor carotenoids predicted subsequent depression. In conclusion, depressive symptoms were cross-sectionally and longitudinally associated with increased F2-isoprostanes and decreased carotenoids. The association with F2-isoprostanes can largely be explained by lifestyle factors, but lower carotenoids were independently associated with depressive symptoms.
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