ArticleTranslational psychiatry2016
Dopamine cross-sensitization between psychostimulant drugs and stress in healthy male volunteers.
Article in Translational psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Pharmacological and non-pharmacological modulation of striatal dopamine release: a meta-analysis of [Molecular psychiatry · 2026Pooled it
- Effect of amphetamines on blood pressure.The Cochrane database of systematic reviews · 2025Pooled it
- Stressful life events are associated with striatal dopamine receptor availability in alcohol dependence.Journal of neural transmission (Vienna, Austria : 1996) · 2019Trial
- Systemic inflammation enhances stimulant-induced striatal dopamine elevation.Translational psychiatry · 2017Trial
- AT1 receptors mediate the effects of cold stress and amphetamine on neurocognitive performance.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [Alcohol, clinical & experimental research · 2025Article
- Amphetamine Induces Sex-Dependent Loss of the Striatal Dopamine Transporter in Sensitized Mice.eNeuro · 2024Article
- Neurochemical Effects of Methylphenidate and Modafinil in Ameliorating Stress-Induced Cognitive Deficits.ACS pharmacology & translational science · 2023Article
- Neurobiology of Aggression-Review of Recent Findings and Relationship with Alcohol and Trauma.Biology · 2023Review
- Suicide Risk in a National VA Sample: Roles of Psychiatric Diagnosis, Behavior Regulation, Substance Use, and Smoking.The Journal of clinical psychiatry · 2022Article
- A three-factor model of common early onset psychiatric disorders: temperament, adversity, and dopamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Mice Cohabiting With Familiar Conspecific in Chronic Stress Condition Exhibit Methamphetamine-Induced Locomotor Sensitization and Augmented Consolation Behavior.Frontiers in behavioral neuroscience · 2022Article
- Acute stress blunts prediction error signals in the dorsal striatum during reinforcement learning.Neurobiology of stress · 2021Article
- Restraint Stress Potentiated Morphine Sensitization: Involvement of Dopamine Receptors within the Nucleus Accumbens.Neurochemical research · 2021Article
- Autophagy-Based Hypothesis on the Role of Brain Catecholamine Response During Stress.Frontiers in psychiatry · 2020Review
- Mechanisms of Shared Vulnerability to Post-traumatic Stress Disorder and Substance Use Disorders.Frontiers in behavioral neuroscience · 2020Review
- Cued for risk: Evidence for an incentive sensitization framework to explain the interplay between stress and anxiety, substance abuse, and reward uncertainty in disordered gambling behavior.Cognitive, affective & behavioral neuroscience · 2019Review
- Interactions of immediate and long-term action regulation in the course and complications of bipolar disorder.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Drug-induced stress responses and addiction risk and relapse.Neurobiology of stress · 2019Review
- A Proof-of-Mechanism Study to Test Effects of the NMDA Receptor Antagonist Lanicemine on Behavioral Sensitization in Individuals With Symptoms of PTSD.Frontiers in psychiatry · 2019Article
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 2 countries.
Funding
Abstract
Dysregulation of the stress response system is a potential etiological factor in the development of and relapse to multiple neuropsychiatric disorders. Previously we reported that repeated intermittent d-amphetamine administration can lead to progressively greater dopamine release, thereby providing evidence of drug-induced neurochemical sensitization. Here, we test the hypothesis that repeated exposure to d-amphetamine increases dopaminergic responses to stress; that is, produces cross-sensitization. Using positron emission tomography, we measured in 17 healthy male volunteers (mean ± s.d. = 22.1 ± 3.4 years) [(11)C]raclopride binding responses to a validated psychosocial stress task before and 2 weeks after a regimen of repeated d-amphetamine (3 × 0.3 mg kg(-1), by mouth; n = 8) or placebo (3 × lactose, by mouth; n = 9). Mood and physiological measurements were recorded throughout each session. Before the d-amphetamine regimen, exposure to the stress task increased behavioral and physiological indices of stress (anxiety, heart rate, cortisol, all P ⩽ 0.05). Following the d-amphetamine regimen, the stress-induced cortisol responses were augmented (P < 0.04), and voxel-based analyses showed larger stress-induced decreases in [(11)C]raclopride non-displaceable binding potential across the striatum. In the placebo group, re-exposure to stress led to smaller clusters of decreased [(11)C]raclopride binding, primarily in the sensorimotor striatum (P < 0.05). Together, this study provides evidence for drug × stress cross-sensitization; moreover, random exposure to stimulants and/or stress cumulatively, while enhancing dopamine release in striatal areas, may contribute to a lowered set point for psychopathologies in which altered dopamine neurotransmission is invoked.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.