Evidence map›Paper›PMID 26905407›Full record

Observational studyInternational urology and nephrology2016

Correlation between nonalcoholic fatty liver and cardiovascular disease in elderly hemodialysis patients.

Radojica V Stolic, Goran Z Trajkovic, Mirjana M Kostic, Sasa R Sovtic, Andrijana M Odalovic, Biljana D Krdzic, Maja V Sipic, Snezana Lazic, Zorica N Sojevic-Timotijevic

Abstract readObservational Study
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In one paragraph

Observational study in International urology and nephrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Editorial.Ultrasound international open · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Radojica V StolicFaculty of Medicine Kragujevac, Clinic of Urology and Nephrology, Clinical Center Kragujevac, University of Kragujevac, Svetozara Markovica 69, Kragujevac, 34000, Serbia. radojica.stolic@med.pr.ac.rs.
Goran Z TrajkovicFaculty of Medicine, Institute of Medical Statistics and Informatics, University of Belgrade, Belgrade, Serbia.
Mirjana M KosticFaculty of Medicine Pristina/K.Mitrovica, University of Pristina, Kosovska Mitrovica, Serbia.
Sasa R SovticFaculty of Medicine Pristina/K.Mitrovica, University of Pristina, Kosovska Mitrovica, Serbia.
Andrijana M OdalovicFaculty of Medicine Pristina/K.Mitrovica, University of Pristina, Kosovska Mitrovica, Serbia.
Biljana D KrdzicFaculty of Medicine Pristina/K.Mitrovica, University of Pristina, Kosovska Mitrovica, Serbia.
Maja V SipicFaculty of Medicine Pristina/K.Mitrovica, University of Pristina, Kosovska Mitrovica, Serbia.
Snezana LazicFaculty of Medicine Pristina/K.Mitrovica, University of Pristina, Kosovska Mitrovica, Serbia.
Zorica N Sojevic-TimotijevicFaculty of Medicine Pristina/K.Mitrovica, University of Pristina, Kosovska Mitrovica, Serbia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe number of elderly patients with end-stage kidney disease is on the rise. Nonalcoholic fatty liver disease (NAFLD) is characterized by parenchymal fat accumulation in patients without information about alcohol abuse. The aim of our study was to determine correlation between NAFLD and cardiovascular diseases in elderly hemodialysis patients.

methodsThe examination was organized as observational and cross-sectional study in elderly patients on hemodialysis. An abdominal ultrasound examination was made in order to define NAFLD. Intima-media thickness of the carotid arteries was quantified by Doppler ultrasound. Biochemical parameters, gender, anthropometric characteristics, duration, adequacy of hemodialysis, blood pressure, smoking and cardiovascular disease were determined. Respondents were divided into a group with NAFLD (37/72 patients, 51 %) and group without NAFLD (35/72 patients, 49 %).

resultsPatients with NAFLD have significantly more cardiovascular disease (p = 0.017) as well as significantly higher values of intima-media thickness of the carotid arteries (p = 0.03) in correlation with patients without NAFLD. Patients without NAFLD have a statistically lower triglyceride (p = 0.04), aspartate aminotransferase (p = 0.006), alanine aminotransferase (p = 0.013) and gamma-glutamyl transpeptidase (p = 0.029) compared to patients with NAFLD. Patients with cardiovascular disease have a higher risk of NAFLD; likewise, patients with NAFLD have a three times higher chance for developing cardiovascular diseases (OR 3.01).

conclusionElderly patients on hemodialysis with cardiovascular disease have a higher risk of NAFLD; likewise, patients with NAFLD have a three times higher chance for developing cardiovascular diseases.

Indexed as

Renal DialysisAgedAge FactorsCardiovascular DiseasesCarotid Intima-Media ThicknessCross-Sectional StudiesFemaleHumansKidney Failure, ChronicMaleNon-alcoholic Fatty Liver DiseaseRisk FactorsCardiovascular diseaseElderly peopleHemodialysisIntima-media thicknessNonalcoholic fatty liver diseaseUltrasonography

Identifiers

PMID26905407

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.