ArticleJournal of the Association for Research in Otolaryngology : JARO2016
Age-Related Changes in Processing Simultaneous Amplitude Modulated Sounds Assessed Using Envelope Following Responses.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Expression of group II mGluRs in the inferior colliculus, medial geniculate body, and auditory cortex increases with age.Neuroscience · 2025Article
- Rapid and objective assessment of auditory temporal processing using dynamic amplitude-modulated stimuli.Communications biology · 2024Article
- Rapid and objective assessment of auditory temporal processing using dynamic amplitude-modulated stimuli.bioRxiv : the preprint server for biology · 2024Article
- Cortical-brainstem interplay during speech perception in older adults with and without hearing loss.Frontiers in neuroscience · 2023Article
- The search for correlates of age-related cochlear synaptopathy: Measures of temporal envelope processing and spatial release from speech-on-speech masking.Hearing research · 2021Article
- On the use of envelope following responses to estimate peripheral level compression in the auditory system.Scientific reports · 2021Article
- Article
- Investigating the Effect of Cochlear Synaptopathy on Envelope Following Responses Using a Model of the Auditory Nerve.Journal of the Association for Research in Otolaryngology : JARO · 2019Article
- Age-related Changes in Neural Coding of Envelope Cues: Peripheral Declines and Central Compensation.Neuroscience · 2019Review
- Top-down or bottom up: decreased stimulus salience increases responses to predictable stimuli of auditory thalamic neurons.The Journal of physiology · 2019Article
- Aging alters envelope representations of speech-like sounds in the inferior colliculus.Neurobiology of aging · 2019Article
- Masking Differentially Affects Envelope-following Responses in Young and Aged Animals.Neuroscience · 2018Article
- Synaptopathy in the Aging Cochlea: Characterizing Early-Neural Deficits in Auditory Temporal Envelope Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Developmental deprivation-induced perceptual and cortical processing deficits in awake-behaving animals.eLife · 2018Article
- Age-related changes in envelope-following responses at equalized peripheral or central activation.Neurobiology of aging · 2017Article
- Responses to Predictable versus Random Temporally Complex Stimuli from Single Units in Auditory Thalamus: Impact of Aging and Anesthesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Listening conditions in the real world involve segregating the stimuli of interest from competing auditory stimuli that differ in their sound level and spectral content. It is in these conditions of complex spectro-temporal processing that listeners with age-related hearing loss experience the most difficulties. Envelope following responses (EFRs) provide objective neurophysiological measures of auditory processing. EFRs were obtained to two simultaneous sinusoidally amplitude modulated (sAM) tones from young and aged Fischer-344 rats. One was held at a fixed suprathreshold sound level (sAM1FL) while the second varied in sound level (sAM2VL) and carrier frequency. EFR amplitudes to sAM1FL in the young decreased with signal-to-noise ratio (SNR), and this reduction was more pronounced when the sAM2VL carrier frequency was spectrally separated from sAM1FL. Aged animals showed similar trends, while having decreased overall response amplitudes compared to the young. These results were replicated using an established computational model of the auditory nerve. The trends observed in the EFRs were shown to be due to the contributions of the low-frequency tails of high-frequency neurons, rather than neurons tuned to the sAM1FL carrier frequency. Modeling changes in threshold and neural loss reproduced some of the changes seen with age, but accuracy improved when combined with an additional decrease representing synaptic loss of auditory nerve neurons. Sound segregation in this case derives primarily from peripheral processing, regardless of age. Contributions by more central neural mechanisms are likely to occur only at low SNRs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.