Evidence map›Paper›PMID 26905270›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2016

Associations of total and free 25OHD and 1,25(OH)2D with serum markers of inflammation in older men.

P Srikanth, R F Chun, M Hewison, J S Adams, R Bouillon, D Vanderschueren, N Lane, P M Cawthon, T Dam, E Barrett-Connor and 7 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 41 citations in OpenAlex.

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  9. Vitamin D Supplementation for Prevention of Type 2 Diabetes Mellitus: To D or Not to D?The Journal of clinical endocrinology and metabolism · 2020
    Review
  10. Free versus total serum 25-hydroxyvitamin D in a murine model of colitis.The Journal of steroid biochemistry and molecular biology · 2019
    Article
  11. Vitamin D Binding Protein: A Historic Overview.Frontiers in endocrinology · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 11 institutions in 3 countries.

P SrikanthDepartment of Public Health and Preventive Medicine, Oregon Health & Science University, Portland, OR, USA.
R F ChunDepartment of Orthopaedic Surgery and Orthopaedic Hospital Research Center, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
M HewisonCentre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, UK.
J S AdamsDepartment of Orthopaedic Surgery and Orthopaedic Hospital Research Center, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
R BouillonClinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium.
D VanderschuerenClinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium.
N LaneDivision of Rheumatology, University of California Davis, Davis, CA, USA.
P M CawthonCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.
T DamDepartment of Medicine, Division of Geriatric Medicine and Aging, Columbia University, New York, NY, USA.
E Barrett-ConnorDivision of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, CA, USA.
L B DanielsDivision of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, CA, USA.
J M ShikanyUniversity of Alabama at Birmingham, Birmingham, AL, USA.
M L StefanickStanford Prevention Research Center, School of Medicine, Stanford University, Stanford, CA, USA.
J A CauleyDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
E S OrwollBone and Mineral Unit, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, CR113, Portland, OR, 97239, USA. orwoll@ohsu.edu.
C M NielsonDepartment of Public Health and Preventive Medicine, Oregon Health & Science University, Portland, OR, USA.
Osteoporotic Fractures in Men (MrOS) Study Research Group
Oregon Health & Science University · USKU Leuven · BEOrthopaedic Hospital · USUniversity of California, San Diego · USCalifornia Pacific Medical Center · USColumbia University · USStanford University · USUniversity of Alabama at Birmingham · USUniversity of Birmingham · GBUniversity of California, Davis · USUniversity of Pittsburgh · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Oregon Clinical and Translational Research InstituteUL1TR000128 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H · 2012 to 2015
$28.7M
Osteoporotic Fractures in Men (MrOS) - San Francisco Coordinating CenterU01AR066160 · NIAMS · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON · 2013 to 2017
$9.3M
Vitamin D Metabolism in LeprosyP50AR063020 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PELLEGRINI, MATTEO · 2012 to 2016
$7.8M
Osteoporotic Fractures in Men (MrOS) - MinneapolisU01AG042145 · NIA · UNIVERSITY OF MINNESOTA · PI ENSRUD, KRISTINE · 2013 to 2019
$5.3M
Osteporotic Fractures in Men (MrOS)- Admin CenterU01AG027810 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2006 to 2017
$5.1M
PITT-MCRC for Rheumatic and Musculoskeletal DiseasesP60AR054731 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KWOH, C KENT · 2007 to 2011
$4.9M
Osteoporotic Fractures in Men (MrOS) - PortlandU01AG042124 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2013 to 2019
$3.0M
Osteoporatic Fractures in Men (MrOS)U01AG042168 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KADO, DEBORAH · 2013 to 2017
$3.0M
Osteoporotic Fractures in Men (Mr. Os) Palo AltoU01AG042143 · NIA · STANFORD UNIVERSITY · PI STEFANICK, MARCIA L. · 2013 to 2017
$3.0M
Osteoporotic Fractures in Men (Mr.OS)U01AG042139 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAULEY, JANE ANN · 2013 to 2017
$2.9M
Osteoporotic Fractures in Men_MrOS Renewal_BirminghamU01AG042140 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SHIKANY, JAMES M · 2013 to 2019
$2.7M
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR000128NIAMS NIH HHS K01 AR062655NIAMS NIH HHS P50 AR063020NIAMS NIH HHS P60 AR054731NIAMS NIH HHS R01 AR063910NIAMS NIH HHS U01 AR066160NIA NIH HHS U01 AG027810NIA NIH HHS U01 AG042124NIA NIH HHS U01 AG042139NIA NIH HHS U01 AG042140NIA NIH HHS U01 AG042143NIA NIH HHS U01 AG042145NIA NIH HHS U01 AG042168
6 · The paper itself

Abstract

unlabelledVitamin D is hypothesized to suppress inflammation. We tested total and free vitamin D metabolites and their association with inflammatory markers. Interleukin-6 levels were lower with higher 25-hydroxyvitamin D. 1,25-dihydroxyvitamin D and free 25OHD associations mirrored those of 25OHD. However, associations for the two metabolites diverged for tumor necrosis factor alpha (TNF-α) soluble receptors.

introductionVitamin D is hypothesized to suppress inflammation, and circulating 25-hydroxyvitamin D (25OHD) and inflammatory markers are inversely correlated. However, total serum 25OHD may not be the best indicator of biologically active vitamin D.

methodsWe tested serum total 25OHD, total 1,25(OH)2D, vitamin D binding protein (DBP), and estimated free 25OHD and free 1,25(OH)2D associations with inflammatory markers serum interleukin-6 (IL-6), TNF-α and their soluble receptors, interleukin-10 (IL-10), and C-reactive protein (CRP) as continuous outcomes and the presence of ≥2 inflammatory markers in the highest quartile as a dichotomous outcome, in a random subcohort of 679 men in the Osteoporotic Fractures in Men (MrOS) study.

resultsIL-6 was lower in men with higher 25OHD (-0.23 μg/mL per standard deviation (SD) increase in 25OHD, 95 % confidence intervals (CI) -0.07 to -0.38 μg/mL) and with higher 1,25(OH)2D (-0.20 μg/mL, 95 % CI -0.0004 to -0.39 μg/mL); free D associations were slightly stronger. 25OHD and DBP, but not 1,25(OH)2D, were independently associated with IL-6. TNF-α soluble receptors were inversely associated with 1,25(OH)2D but positively associated with 25OHD, and each had independent effects. The strongest association with ≥2 inflammatory markers in the highest quartile was for free 1,25(OH)2D (odds ratios (OR) 0.70, 95 % CI 0.54 to 0.89 per SD increase in free 1,25(OH)2D).

conclusionsAssociations of 1,25(OH)2D and free 25OHD with IL-6 mirrored those of 25OHD, suggesting that 1,25(OH)2D and free D do not improve upon 25OHD in population-based IL-6 studies. However, associations for the two metabolites diverged for TNF-α soluble receptor, warranting examination of both metabolites in studies of TNF-α and its antagonists.

Indexed as

AgedAged, 80 and overBiomarkersHumansInflammationInterleukin-6MaleReceptors, Tumor Necrosis FactorVitamin D1,25-dihydroxyvitamin D25-hydroxyvitamin DBiomarkersIL6 protein, humanInterleukin-6Receptors, Tumor Necrosis FactorVitamin DElderlyFree 1,25(OH)2DFree 25OHDInflammationMenTotal 1,25(OH)2DTotal 25OHD

Identifiers

PMID26905270
PMCPMC4902735
OpenAlexW2287262541

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.