ArticleJournal of neural engineering2016
Changes in ganglion cell physiology during retinal degeneration influence excitability by prosthetic electrodes.
Article in Journal of neural engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Resting-state electroretinography reveals pathological retinal oscillations in retinitis pigmentosa mice and patients.Nature communications · 2026Article
- Quantitative Markers of Neural Changes, Retinal Thickness, and Responses to Electrical Stimulation in Retinal Degeneration.Ophthalmology science · 2026Article
- Restoration of Sight with Electronic Retinal Prostheses.Annual review of vision science · 2025Review
- Optimizing electrical stimulation parameters to enhance visual cortex activation in retina degeneration rats.Scientific reports · 2025Article
- Foveal RGCs develop altered calcium dynamics weeks after photoreceptor ablation.bioRxiv : the preprint server for biology · 2024Article
- Electronic Retinal Prostheses.Cold Spring Harbor perspectives in medicine · 2023Review
- Retinal ganglion cells undergo cell type-specific functional changes in a computational model of cone-mediated retinal degeneration.Frontiers in neuroscience · 2023Article
- Implications of Neural Plasticity in Retinal Prosthesis.Investigative ophthalmology & visual science · 2022Article
- Retinal ganglion cell desensitization is mitigated by varying parameter constant excitation pulse trains.Frontiers in cellular neuroscience · 2022Article
- Differences in the spatial fidelity of evoked and spontaneous signals in the degenerating retina.Frontiers in cellular neuroscience · 2022Article
- Morphological Factors that Underlie Neural Sensitivity to Stimulation in the Retina.Advanced nanobiomed research · 2021Article
- Retinal Degeneration Reduces Consistency of Network-Mediated Responses Arising in Ganglion Cells to Electric Stimulation.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2020Article
- The relationship between morphological properties and thresholds to extracellular electric stimulation in α RGCs.Journal of neural engineering · 2020Article
- Probing and predicting ganglion cell responses to smooth electrical stimulation in healthy and blind mouse retina.Scientific reports · 2020Article
- Stimulation Strategies for Improving the Resolution of Retinal Prostheses.Frontiers in neuroscience · 2020Review
- Retinotopic Responses in the Visual Cortex Elicited by Epiretinal Electrical Stimulation in Normal and Retinal Degenerate Rats.Translational vision science & technology · 2018Article
- Direct measurement of bipolar cell responses to electrical stimulation in wholemount mouse retina.Journal of neural engineering · 2018Article
- Increasing Electrical Stimulation Efficacy in Degenerated Retina: Stimulus Waveform Design in a Multiscale Computational Model.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2018Article
- Electric stimulus duration alters network-mediated responses depending on retinal ganglion cell type.Journal of neural engineering · 2018Article
- Changes in intrinsic excitability of ganglion cells in degenerated retinas of RCS rats.International journal of ophthalmology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveHere we investigate ganglion cell physiology in healthy and degenerating retina to test its influence on threshold to electrical stimulation. APPROACH: Age-related Macular Degeneration and Retinitis Pigmentosa cause blindness via outer retinal degeneration. Inner retinal pathways that transmit visual information to the central brain remain intact, so direct electrical stimulation from prosthetic devices offers the possibility for visual restoration. Since inner retinal physiology changes during degeneration, we characterize physiological properties and responses to electrical stimulation in retinal ganglion cells (RGCs) of both wild type mice and the rd10 mouse model of retinal degeneration. MAIN
resultsOur aggregate results support previous observations that elevated thresholds characterize diseased retinas. However, a physiology-driven classification scheme reveals distinct sub-populations of ganglion cells with thresholds either normal or strongly elevated compared to wild-type. When these populations are combined, only a weakly elevated threshold with large variance is observed. The cells with normal threshold are more depolarized at rest and exhibit periodic oscillations. SIGNIFICANCE: During degeneration, physiological changes in RGCs affect the threshold stimulation currents required to evoke action potentials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.