ArticleScientific reports2016
Period-independent novel circadian oscillators revealed by timed exercise and palatable meals.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Elucidation of daily timed-palatable meal-anticipatory activity in the circadian system of mice.American journal of physiology. Gastrointestinal and liver physiology · 2026Article
- Methamphetamine alters the circadian oscillator and its couplings on multiple scales inPNAS nexus · 2025Article
- Dietary restriction modulates ultradian rhythms and autocorrelation properties in mice behavior.Communications biology · 2024Article
- A time memory engram embedded in a light-entrainable circadian clock.Current biology : CB · 2023Article
- Binge eating, overeating and food addiction: Approaches for examining food overconsumption in laboratory rodents.Progress in neuro-psychopharmacology & biological psychiatry · 2023Review
- Multiscale Time-resolved Analysis Reveals Remaining Behavioral Rhythms in Mice Without Canonical Circadian Clocks.Journal of biological rhythms · 2022Article
- Genetics and functional significance of the understudied methamphetamine sensitive circadian oscillator (MASCO).F1000Research · 2022Review
- Sleep dysregulation in binge eating disorder and "food addiction": the orexin (hypocretin) system as a potential neurobiological link.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Review
- The Mysterious Food-Entrainable Oscillator: Insights from Mutant and Engineered Mouse Models.Journal of biological rhythms · 2018Review
- Circadian Rhythms, Exercise, and Cardiovascular Health.Journal of circadian rhythms · 2018Review
- Circadian-scale periodic bursts in theta and gamma-band coherence between hippocampus, cingulate and insular cortices.Neurobiology of sleep and circadian rhythms · 2017Article
- Computational modeling of the cell-autonomous mammalian circadian oscillator.BMC systems biology · 2017Article
- The Running Wheel Enhances Food Anticipatory Activity: An Exploratory Study.Frontiers in behavioral neuroscience · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian circadian system is a hierarchical network of oscillators organized to optimally coordinate behavior and physiology with daily environmental cycles. The suprachiasmatic nucleus (SCN) of the hypothalamus is at the top of this hierarchy, synchronizing to the environmental light-dark cycle, and coordinates the phases of peripheral clocks. The Period genes are critical components of the molecular timekeeping mechanism of these clocks. Circadian clocks are disabled in Period1/2/3 triple mutant mice, resulting in arrhythmic behavior in constant conditions. We uncovered rhythmic behavior in this mutant by simply exposing the mice to timed access to a palatable meal or running wheel. The emergent circadian behavior rhythms free-ran for many cycles under constant conditions without cyclic environmental cues. Together, these data demonstrate that the palatable meal-inducible circadian oscillator (PICO) and wheel-inducible circadian oscillator (WICO) are generated by non-canonical circadian clocks. Entrainment of these novel oscillators by palatable snacks and timed exercise could become novel therapeutics for human conditions caused by disruptions of the circadian clocks.
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