ArticleCell reports2016
Hox Proteins Coordinate Motor Neuron Differentiation and Connectivity Programs through Ret/Gfrα Genes.
Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 79 citations in OpenAlex.
- HOXA5-driven transcriptional program in lung development.Developmental biology · 2025Article
- An integrated transcriptomic approach for identifying enhancers in limb motor pools.Scientific reports · 2025Article
- TheiScience · 2025Article
- Loss of Hoxa5 function affects Hox gene expression in different biological contexts.Scientific reports · 2024Article
- Multimodal Hox5 activity generates motor neuron diversity.Communications biology · 2024Article
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- Single-cell transcriptomic analysis reveals diversity within mammalian spinal motor neurons.Nature communications · 2023Article
- Little skate genome provides insights into genetic programs essential for limb-based locomotion.eLife · 2022Article
- Modular derivation of diverse, regionally discrete human posterior CNS neurons enables discovery of transcriptomic patterns.Science advances · 2022Article
- A developmental pathway for epithelial-to-motoneuron transformation in C. elegans.Cell reports · 2022Article
- The Cell Autonomous and Non-Cell Autonomous Aspects of Neuronal Vulnerability and Resilience in Amyotrophic Lateral Sclerosis.Biology · 2022Review
- Article
- The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development.Nature communications · 2022Article
- Article
- Establishing the Molecular and Functional Diversity of Spinal Motoneurons.Advances in neurobiology · 2022Article
- Impact of the Epigenetically Regulated Hoxa-5 Gene in Neural Differentiation from Human Adipose-Derived Stem Cells.Biology · 2021Article
- Discovering differential genome sequence activity with interpretable and efficient deep learning.PLoS computational biology · 2021Article
- MicroRNA governs bistable cell differentiation and lineage segregation via a noncanonical feedback.Molecular systems biology · 2021Article
- Molecular correlates of muscle spindle and Golgi tendon organ afferents.Nature communications · 2021Article
- Emerging Roles for Hox Proteins in the Last Steps of Neuronal Development in Worms, Flies, and Mice.Frontiers in neuroscience · 2021Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The accuracy of neural circuit assembly relies on the precise spatial and temporal control of synaptic specificity determinants during development. Hox transcription factors govern key aspects of motor neuron (MN) differentiation; however, the terminal effectors of their actions are largely unknown. We show that Hox/Hox cofactor interactions coordinate MN subtype diversification and connectivity through Ret/Gfrα receptor genes. Hox and Meis proteins determine the levels of Ret in MNs and define the intrasegmental profiles of Gfrα1 and Gfrα3 expression. Loss of Ret or Gfrα3 leads to MN specification and innervation defects similar to those observed in Hox mutants, while expression of Ret and Gfrα1 can bypass the requirement for Hox genes during MN pool differentiation. These studies indicate that Hox proteins contribute to neuronal fate and muscle connectivity through controlling the levels and pattern of cell surface receptor expression, consequently gating the ability of MNs to respond to limb-derived instructive cues.
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Registered trials
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