ArticleCell reports2016
Early Developmental Program Shapes Colony Morphology in Bacteria.
Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Bacterial nanotubes extend from a tubeosome organelle to establish an intercellular bridge.bioRxiv : the preprint server for biology · 2026Article
- Atomic Force Microsocopy: Key Unconventional Approach for Bacterial Nanotubes Characterization In Vivo.ACS omega · 2024Article
- Diverse regulatory pathways modulate bet hedging of competence induction in epigenetically-differentiated phase variants of Streptococcus pneumoniae.Nucleic acids research · 2023Article
- Contact Area and Deformation ofLangmuir : the ACS journal of surfaces and colloids · 2023Article
- Aqueous habitats and carbon inputs shape the microscale geography and interaction ranges of soil bacteria.Communications biology · 2023Article
- Bioelectric Fields at the Beginnings of Life.Bioelectricity · 2022Review
- Formation of unique T-shape budding and differential impacts of low surface water on Bacillus mycoides rhizoidal colony.Archives of microbiology · 2022Article
- Mechanical limitation of bacterial motility mediated by growing cell chains.Biophysical journal · 2022Article
- Bacteria elicit a phage tolerance response subsequent to infection of their neighbors.The EMBO journal · 2022Article
- Article
- Bacterial nanotubes as a manifestation of cell death.Nature communications · 2020Article
- The YmdB protein regulates biofilm formation dependent on the repressor SinR in Bacillus cereus 0-9.World journal of microbiology & biotechnology · 2020Article
- Emergence of active nematics in chaining bacterial biofilms.Nature communications · 2019Article
- Social behaviours by Bacillus subtilis: quorum sensing, kin discrimination and beyond.Molecular microbiology · 2018Review
- Article
- Verticalization of bacterial biofilms.Nature physics · 2018Article
- Mineralization and cementing properties of bio-carbonate cement, bio-phosphate cement, and bio-carbonate/phosphate cement: a review.Environmental science and pollution research international · 2018Review
- Interspecies nutrient extraction and toxin delivery between bacteria.Nature communications · 2017Article
- Deficiency in Lipoteichoic Acid Synthesis Causes a Failure in Executing the Colony Developmental Program inFrontiers in microbiology · 2017Article
- Variations and heredity in bacterial colonies.Communicative & integrative biology · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When grown on a solid surface, bacteria form highly organized colonies, yet little is known about the earliest stages of colony establishment. Following Bacillus subtilis colony development from a single progenitor cell, a sequence of highly ordered spatiotemporal events was revealed. Colony was initiated by the formation of leading-cell chains, deriving from the colony center and extending in multiple directions, typically in a "Y-shaped" structure. By eradicating particular cells during these early stages, we could influence the shape of the resulting colony and demonstrate that Y-arm extension defines colony size. A mutant in ymdB encoding a phosphodiesterase displayed unordered developmental patterns, indicating a role in guiding these initial events. Finally, we provide evidence that intercellular nanotubes contribute to proper colony formation. In summary, we reveal a "construction plan" for building a colony and provide the initial molecular basis for this process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.