Evidence map›Paper›PMID 26904722›Full record

ArticleInternational journal of bacteriology2013

Inflammatory Responses to Salmonella Infections Are Serotype-Specific.

Zhanna Ktsoyan, Karine Ghazaryan, Gayane Manukyan, Anush Martirosyan, Armine Mnatsakanyan, Karine Arakelova, Zaruhi Gevorgyan, Anahit Sedrakyan, Ara Asoyan, Anna Boyajyan and 1 more

Abstract read
In one paragraph

Article in International journal of bacteriology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Differential induction of total IgE by two Salmonella enterica serotypes.Frontiers in cellular and infection microbiology · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhanna KtsoyanInstitute of Molecular Biology National Academy of Sciences of Republic of Armenia, Hasratyan 7, 0014 Yerevan, Armenia.
Karine GhazaryanInstitute of Molecular Biology National Academy of Sciences of Republic of Armenia, Hasratyan 7, 0014 Yerevan, Armenia.
Gayane ManukyanInstitute of Molecular Biology National Academy of Sciences of Republic of Armenia, Hasratyan 7, 0014 Yerevan, Armenia.
Anush MartirosyanInstitute of Molecular Biology National Academy of Sciences of Republic of Armenia, Hasratyan 7, 0014 Yerevan, Armenia.
Armine Mnatsakanyan"Nork" Clinical Hospital of Infectious Diseases, Ministry of Health of Republic of Armenia, Armenakyan 153, 0047 Yerevan, Armenia.
Karine ArakelovaInstitute of Molecular Biology National Academy of Sciences of Republic of Armenia, Hasratyan 7, 0014 Yerevan, Armenia.
Zaruhi Gevorgyan"Nork" Clinical Hospital of Infectious Diseases, Ministry of Health of Republic of Armenia, Armenakyan 153, 0047 Yerevan, Armenia.
Anahit SedrakyanInstitute of Molecular Biology National Academy of Sciences of Republic of Armenia, Hasratyan 7, 0014 Yerevan, Armenia.
Ara Asoyan"Nork" Clinical Hospital of Infectious Diseases, Ministry of Health of Republic of Armenia, Armenakyan 153, 0047 Yerevan, Armenia.
Anna BoyajyanInstitute of Molecular Biology National Academy of Sciences of Republic of Armenia, Hasratyan 7, 0014 Yerevan, Armenia.
Rustam AminovFaculty of Medical Sciences, University of the West Indies, Mona, Kingston 7, Jamaica.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The main purpose of this study was to investigate the profile of inflammatory response in patients with acute salmonellosis caused by two serotypes of Salmonella enterica, S. Enteritidis and S. Typhimurium, as well as in convalescent patients with previous acute disease caused by S. Enteritidis. Patients with acute disease showed significantly elevated levels of IL-1β, IL-17, IL-10, and calprotectin compared to healthy control subjects. In convalescent patients, these markers were also significantly elevated, with the exception of IL-1β. Multivariate statistical analyses with the use of these variables produced models with a good predictive accuracy resulting in excellent separation of the diseased and healthy cohorts studied. Overall, the results suggest that the profile of inflammatory response in this disease is determined, to a significant degree, by the serotype of Salmonella, and the profile of certain cytokines and calprotectin remains abnormal for a number of months following the acute disease stage.

Identifiers

PMID26904722
PMCPMC4745457

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.