ArticleJournal of investigative medicine high impact case reports
Spontaneous Tumor Lysis Syndrome: A Case Report and Critical Evaluation of Current Diagnostic Criteria and Optimal Treatment Regimens.
Article in Journal of investigative medicine high impact case reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Spontaneous tumour lysis syndrome in chronic lymphocytic leukaemia: an unanticipated complication of an undiagnosed disease.BMJ case reports · 2024Article
- Transformed Plasmablastic Lymphoma Presenting With Marked Lymphocytosis and Spontaneous Tumor Lysis Syndrome.Journal of hematology · 2023Article
- Acute kidney injury following induction of chemotherapy: Diagnosis and management in critical care.Journal of the Intensive Care Society · 2023Article
- Article
- Heterogeneity in the diagnosis of plasmablastic lymphoma, plasmablastic myeloma, and plasmablastic neoplasm: a scoping review.International journal of hematology · 2021Article
- Article
- Tumor Lysis Syndrome: Introduction of a Cutaneous Variant and a New Classification System.Cureus · 2021Review
- Article
- Spontaneous Tumor Lysis Syndrome in T-Cell Leukemia.Cureus · 2020Article
- Tumor lysis syndrome in childhood malignancies.Drugs in context · 2020Review
- A Rare Oncologic Emergency: Spontaneous Tumor Lysis Syndrome in Metastatic Colon Adenocarcinoma.Clinical practice and cases in emergency medicine · 2019Article
- Acute Liver Failure as the Leading Manifestation of Spontaneous Tumour Lysis Syndrome in a Patient with NonHodgkin Lymphoma: Do Current Diagnostic Criteria of Tumour Lysis Syndrome Need Re-Evaluation?Case reports in critical care · 2019Article
- Spontaneous Tumor Lysis Syndrome Secondary to Small-Cell Neuroendocrine Carcinoma of Unknown Origin: A Rare Case Report and Literature Review.Case reports in oncological medicine · 2019Article
- Spontaneous tumor lysis syndrome in T-cell malignancy: two case reports.Stem cell investigation · 2019Article
- Spontaneous tumor lysis syndrome occurring in untreated uterine cancer.Gynecologic oncology reports · 2017Article
- Prevention and treatment of tumor lysis syndrome, and the efficacy and role of rasburicase.OncoTargets and therapy · 2017Review
- Tumor Lysis Syndrome in Patients with Hematological Malignancies.Journal of oncology · 2017Review
- Acute tumor lysis syndrome after proximal splenic artery embolization.Radiology case reports · 2016Article
- Spontaneous Tumor Lysis Syndrome in a Patient with Bulky Chronic Lymphocytic Leukemia Diagnosed after Resolution of Symptoms.Case reports in oncologyArticle
- Fatal Spontaneous Tumor Lysis Syndrome in a Patient with Metastatic Colon Cancer: A Clinical Case of Rare Oncological Emergency.Case reports in gastroenterologyArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Tumor lysis syndrome (TLS) is a known complication of malignancy and its treatment. The incidence varies on malignancy type, but is most common with hematologic neoplasms during cytotoxic treatment. Spontaneous TLS is thought to be rare. This case study is of a 62-year-old female admitted with multisystem organ failure, with subsequent diagnosis of aggressive B cell lymphoma. On admission, laboratory abnormalities included renal failure, elevated uric acid (20.7 mg/dL), and 3+ amorphous urates on urinalysis. Oliguric renal failure persisted despite aggressive hydration and diuretic use, requiring initiation of hemodialysis prior to chemotherapy. Antihyperuricemic therapy and hemodialysis were used to resolve hyperuricemia. However, due to multisystem organ dysfunction syndrome with extremely poor prognosis, the patient ultimately expired in the setting of a terminal ventilator wean. Although our patient did not meet current TLS criteria, she required hemodialysis due to uric acid nephropathy, a complication of TLS. This poses the clinical question of whether adequate diagnostic criteria exist for spontaneous TLS and if the lack of currently accepted guidelines has resulted in the underestimation of its incidence. Allopurinol and rasburicase are commonly used for prevention and treatment of TLS. Although both drugs decrease uric acid levels, allopurinol mechanistically prevents formation of the substrate rasburicase acts to solubilize. These drugs were administered together in our patient, although no established guidelines recommend combined use. This raises the clinical question of whether combined therapy is truly beneficial or, conversely, detrimental to patient outcomes.
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Registered trials
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