ReviewBioMed research international2016
Diagnostic Methods of Helicobacter pylori Infection for Epidemiological Studies: Critical Importance of Indirect Test Validation.
Review in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03310255 (Helicobacter Pylori Infection in Renal Transplant Patients), which is not on this map. Cited by 68 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Helicobacter Pylori Infection in Renal Transplant Patients
Who cites it
68 citing papers in PubMed, 5 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Salt intake and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project.Cancer causes & control : CCC · 2022Pooled it
- Prevalence ofFrontiers in oncology · 2022Pooled it
- Helicobacter pylori infection as a risk factor for diabetes: a meta-analysis of case-control studies.BMC gastroenterology · 2020Pooled it
- Non-invasive diagnostic tests for Helicobacter pylori infection.The Cochrane database of systematic reviews · 2018Pooled it
- Accuracy of testing for anti-BMJ open · 2017Pooled it
- Review of Peptic Ulcer Disease: Insights from Pathophysiology, Mechanisms, Pharmacotherapy, Phytotherapy, and Case Reports.Drug design, development and therapy · 2026Review
- On the Role of Food in the Transmission ofFoods (Basel, Switzerland) · 2025Review
- Pathogenicity and virulence ofVirulence · 2025Review
- Raman spectroscopy and machine learning for early detection of gastric cancer and Helicobacter pylori with gastric juice.Scientific reports · 2025Article
- Article
- Prevalence of Helicobacter pylori infection in patients with upper gastrointestinal disorders using different methods in Khuzestan, Southwest Iran.Molecular biology reports · 2025Article
- Development of a colorimetric loop-mediated isothermal amplification assay for Helicobacter pylori detection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- ImprovingFrontiers in gastroenterology (Lausanne, Switzerland) · 2025Article
- Prevalence of Helicobacter pylori cagA virulence factor and validation of serological tests in a population from Northeastern Brazil.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025Article
- The role of MAPK pathway in gastric cancer: unveiling molecular crosstalk and therapeutic prospects.Journal of translational medicine · 2024Review
- Barriers and facilitators of prevention of infections related to cancer: A systematic literature review.Heliyon · 2024Article
- Data-driven rapid detection ofHeliyon · 2024Article
- Assessment ofHeliyon · 2024Article
- Upper gastrointestinal bleeding: Diagnosis ofHealth science reports · 2024Article
- Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
Abstract
Among the methods developed to detect H. pylori infection, determining the gold standard remains debatable, especially for epidemiological studies. Due to the decreasing sensitivity of direct diagnostic tests (histopathology and/or immunohistochemistry [IHC], rapid urease test [RUT], and culture), several indirect tests, including antibody-based tests (serology and urine test), urea breath test (UBT), and stool antigen test (SAT) have been developed to diagnose H. pylori infection. Among the indirect tests, UBT and SAT became the best methods to determine active infection. While antibody-based tests, especially serology, are widely available and relatively sensitive, their specificity is low. Guidelines indicated that no single test can be considered as the gold standard for the diagnosis of H. pylori infection and that one should consider the method's advantages and disadvantages. Based on four epidemiological studies, culture and RUT present a sensitivity of 74.2-90.8% and 83.3-86.9% and a specificity of 97.7-98.8% and 95.1-97.2%, respectively, when using IHC as a gold standard. The sensitivity of serology is quite high, but that of the urine test was lower compared with that of the other methods. Thus, indirect test validation is important although some commercial kits propose universal cut-off values.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.