Evidence map›Paper›PMID 26904516›Full record

ReviewFrontiers in cellular and infection microbiology2016

Shigella Iron Acquisition Systems and their Regulation.

Yahan Wei, Erin R Murphy

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Genomic profiling of ESBL/AmpC-producingFrontiers in microbiology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Iron robbery by intracellular pathogen via bacterial effector-induced ferritinophagy.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  9. Article
  10. New Insights Into DAEC and EAEC Pathogenesis and Phylogeny.Frontiers in cellular and infection microbiology · 2020
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. RNA Thermometers in Bacterial Pathogens.Microbiology spectrum · 2018
    Review
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yahan WeiDepartment of Biological Sciences, Ohio University Athens, OH, USA.
Erin R MurphyDepartment of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University Athens, OH, USA.
Ohio University · US

Funding

Analysis of a Shigella dysenteriae Fe regulated promoterF32GM069312 · NIGMS · UNIVERSITY OF TEXAS AUSTIN · PI MURPHY, ERIN R · 2003 to 2005
$139k
NIGMS NIH HHS F32 GM069312
6 · The paper itself

Abstract

Survival of Shigella within the host is strictly dependent on the ability of the pathogen to acquire essential nutrients, such as iron. As an innate immune defense against invading pathogens, the level of bio-available iron within the human host is maintained at exceeding low levels, by sequestration of the element within heme and other host iron-binding compounds. In response to sequestration mediated iron limitation, Shigella produce multiple iron-uptake systems that each function to facilitate the utilization of a specific host-associated source of nutrient iron. As a mechanism to balance the essential need for iron and the toxicity of the element when in excess, the production of bacterial iron acquisition systems is tightly regulated by a variety of molecular mechanisms. This review summarizes the current state of knowledge on the iron-uptake systems produced by Shigella species, their distribution within the genus, and the molecular mechanisms that regulate their production.

Indexed as

Biological TransportGene Expression Regulation, BacterialHemeHumansIronShigellaHemeIroniron acquisitionpathogenicityregulationShigellavirulence

Identifiers

PMID26904516
PMCPMC4746246
OpenAlexW2292216472

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.