ArticleCase reports in endocrinology2016
An Ectopic ACTH Secreting Metastatic Parotid Tumour.
Article in Case reports in endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Intestinal Perforation in ACTH-Dependent Cushing's Syndrome.BioMed research international · 2019Trial
- Article
- Cushing's syndrome due to ectopic adrenocorticotropin secretion by a parotid carcinoma.Archives of endocrinology and metabolism · 2022Article
- Multiple hormone secretion may indicate worse prognosis in patients with ectopic Cushing's syndrome.Hormones (Athens, Greece) · 2020Article
- Ectopic ACTH Production and Cushing's Syndrome in a Patient with Parotid Acinic Cell Carcinoma with High-Grade Transformation: Tumor Context and Clinical Implications.Head and neck pathology · 2020Article
- Ectopic Cushing's Syndrome Unveiling a Metastatic Parotid Carcinoma.Case reports in endocrinology · 2019Article
- Diverticular Perforation: A Fatal Complication to Forestall in Cushing Syndrome.The Journal of clinical endocrinology and metabolism · 2018Article
- Ectopic ACTH Secretion Secondary to Metastatic Acinic Cell Carcinoma of the Parotid Gland: A Case Report and Review of Current Evidence for Systemic Therapy.Journal of investigative medicine high impact case reportsReview
- Ectopic ACTH Production Caused by Metastatic Parotid Gland Acinic Cell Carcinoma.AACE clinical case reportsArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 60-year old woman presented with features of Cushing's syndrome (CS) secondary to an ectopic adrenocorticotropic hormone (ACTH) secreting metastatic parotid tumour 3 years after excision of the original tumour. She subsequently developed fatal intestinal perforation and unfortunately died despite best possible medical measures. Ectopic ACTH secretion accounts for 5-10% of all patients presenting with ACTH dependent hypercortisolism; small cell carcinoma of lung (SCLC) and neuroendocrine tumours (NET) account for the majority of such cases. Although there are 4 previous case reports of ectopic ACTH secreting salivary tumours in literature, to our knowledge this is the first published case report in which the CS developed after 3 years of what was deemed as a successful surgical excision of primary salivary tumour. Our patient initially had nonspecific symptoms which may have contributed to a delay in diagnosis. Perforation of sigmoid colon is a recognised though underdiagnosed complication associated with steroid therapy and hypercortisolism. This case demonstrates the challenges faced in diagnosis as well as management of patients with CS apart from the practical difficulties faced while trying to identify source of ectopic ACTH.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.