ReviewNeural plasticity2016
Impaired Functional Connectivity in the Prefrontal Cortex: A Mechanism for Chronic Stress-Induced Neuropsychiatric Disorders.
Review in Neural plasticity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Transcranial alternating current stimulation (tACS): from basic mechanisms towards first applications in psychiatry.European archives of psychiatry and clinical neuroscience · 2021Pooled it
- Organization of mouse prefrontal cortex subnetwork revealed by spatial single-cell multi-omic analysis of SPIDER-Seq.National science review · 2026Article
- Oral health conditions and domain-specific cognitive decline in older adults: evidence from the Baltimore Longitudinal Study of Aging 2005-2024.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Review
- Chronic Unpredictable Stress Impairs Social Behaviour in Adult Male Rats: Correlations with Dopamine and Serotonin Levels.Molecular neurobiology · 2025Article
- Home-Cage Training for Non-Human Primates: An Opportunity to Reduce Stress and Study Natural Behavior in Neurophysiology Experiments.Animals : an open access journal from MDPI · 2025Review
- Single-dose psychedelic enhances cognitive flexibility and reversal learning in mice weeks after administration.Psychedelics · 2025Article
- Psychedelic enhancement of flexible learning weeks after a single dose.bioRxiv : the preprint server for biology · 2024Article
- Greater Neighborhood Disadvantage Is Associated with Alterations in Fetal Functional Brain Network Structure.The Journal of pediatrics · 2024Observational
- Co-administration of midazolam and psilocybin: differential effects on subjective quality versus memory of the psychedelic experience.Translational psychiatry · 2024Article
- Neurosteroid influence on affective tone.Neuroscience and biobehavioral reviews · 2023Review
- Integrative bioinformatics and artificial intelligence analyses of transcriptomics data identified genes associated with major depressive disorders includingNeurobiology of stress · 2023Article
- Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B vitamins: an fMRI study.Frontiers in nutrition · 2023Article
- Adolescent chronic unpredictable stress leads to increased anxiety and attention deficit/hyperactivity-like symptoms in adulthood.Psychopharmacology · 2022Article
- Protective effects of ThaiJournal of traditional and complementary medicine · 2022Article
- Inflammation-driven brain and gut barrier dysfunction in stress and mood disorders.The European journal of neuroscience · 2022Review
- Impact of Perceived Stress and Immune Status on Decision-Making Abilities during COVID-19 Pandemic Lockdown.Behavioral sciences (Basel, Switzerland) · 2021Article
- Suppression of pyramidal neuron G protein-gated inwardly rectifying K+ channel signaling impairs prelimbic cortical function and underlies stress-induced deficits in cognitive flexibility in male, but not female, mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Catalysts for change: the cellular neurobiology of psychedelics.Molecular biology of the cell · 2021Review
- Disrupted upregulation of salience network connectivity during acute stress in siblings of schizophrenia patients.Psychological medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Chronic stress-related psychiatric diseases, such as major depression, posttraumatic stress disorder, and schizophrenia, are characterized by a maladaptive organization of behavioral responses that strongly affect the well-being of patients. Current evidence suggests that a functional impairment of the prefrontal cortex (PFC) is implicated in the pathophysiology of these diseases. Therefore, chronic stress may impair PFC functions required for the adaptive orchestration of behavioral responses. In the present review, we integrate evidence obtained from cognitive neuroscience with neurophysiological research with animal models, to put forward a hypothesis that addresses stress-induced behavioral dysfunctions observed in stress-related neuropsychiatric disorders. We propose that chronic stress impairs mechanisms involved in neuronal functional connectivity in the PFC that are required for the formation of adaptive representations for the execution of adaptive behavioral responses. These considerations could be particularly relevant for understanding the pathophysiology of chronic stress-related neuropsychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.