ArticleJournal of thoracic disease2016
Mitral valve repair for ischemic mitral regurgitation: lessons from the Cardiothoracic Surgical Trials Network randomized study.
Article in Journal of thoracic disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Moderate ischemic mitral incompetence: does it worth more ischemic time?General thoracic and cardiovascular surgery · 2020Trial
- Mitral repair with annuloplasty for moderate ischemic mitral regurgitation in people undergoing coronary artery bypass surgery.The Cochrane database of systematic reviews · 2025Article
- Secondary mitral regurgitation surgical management: a narrative review.Cardiovascular diagnosis and therapy · 2024Review
- Long-term follow-up of posterior mitral leaflet extension for Type IIIb ischemic mitral regurgitation.JTCVS open · 2024Article
- 2023 National Heart Center/Saudi Heart Association Focused Update of the 2019 Saudi Heart Association Guidelines for the Management of Heart Failure.Journal of the Saudi Heart Association · 2023Article
- Left ventricular remodeling, mechanics, and the COAPT trial.Frontiers in cardiovascular medicine · 2023Article
- Mitral valve repair in papillary muscle rupture.Annals of cardiothoracic surgery · 2022Review
- Alterations in Intracardiac Flow Patterns Affect Mitral Leaflets Dynamics in a Model of Ischemic Mitral Regurgitation.Cardiovascular engineering and technology · 2021Article
- Clinical Outcomes of a Customized Mitral Valve Plasty for Functional Mitral Regurgitation with a Low Ejection Fraction and Implications for Preoperative Right Ventricular Function.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2021Article
- Saudi Heart Association (SHA) guidelines for the management of heart failure.Journal of the Saudi Heart Association · 2019Review
- Observational
- Mid-term results of mitral valve repair for ischemic mitral regurgitation adjusted according to the degree of remodeling progression.General thoracic and cardiovascular surgery · 2018Article
- Topographic mapping of left ventricular regional contractile injury in ischemic mitral regurgitation.The Journal of thoracic and cardiovascular surgery · 2017Article
- Surgical Treatment of Ischemic Mitral Regurgitation: Valve Repair Versus Replacement.Current cardiology reports · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Approximately 30% to 50% of patients will develop ischemic mitral regurgitation (MR) after a myocardial infarction, which is a result of progressive left ventricular remodeling and dysfunction of the subvalvular apparatus, and portends a poor long-term prognosis. Surgical treatment is centered on mitral valve repair utilizing a restrictive annuloplasty, or valve replacement with preservation of the subvalvular apparatus. In the recent Cardiothoracic Surgical Trials Network (CSTN) study, patients with severe ischemic MR were randomized to mitral valve repair with a restrictive annuloplasty versus chordal-sparing valve replacement, and concomitant coronary artery bypass grafting, if indicated. At 2-year follow-up, mitral valve repair was associated with a significantly higher incidence of moderate or greater recurrent MR and heart failure, with no difference in the indices of left ventricular reverse remodeling, as compared with valve replacement. The current appraisal aims to provide insight into the CSTN trial results, and discusses the evidence supporting a pathophysiologic-guided repair strategy incorporating combined annuloplasty and subvalvular repair techniques to optimize the outcomes of mitral valve repair in ischemic MR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.