Evidence map›Paper›PMID 26904159›Full record

ReviewThe World Allergy Organization journal2016

Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases.

Dean D Metcalfe, Ruby Pawankar, Steven J Ackerman, Cem Akin, Frederic Clayton, Franco H Falcone, Gerald J Gleich, Anne-Marie Irani, Mats W Johansson, Amy D Klion and 10 more

Open access · goldAbstract readReview
In one paragraph

Review in The World Allergy Organization journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
9.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 150 citations in OpenAlex.

  1. Trial
  2. Trial
  3. CD25 expression marks an activated mast cell population in human nasal polyposis.The Journal of allergy and clinical immunology · 2026
    Article
  4. Article
  5. Review
  6. Mast cell mediators in hereditary angioedema.Orphanet journal of rare diseases · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Mast Cells in Cardiac Remodeling: Focus on the Right Ventricle.Journal of cardiovascular development and disease · 2024
    Review
  19. Article
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 15 institutions in 7 countries.

Dean D MetcalfeLaboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 USA.
Ruby PawankarDivision of Allergy, Department of Pediatrics, Nippon Medical School, Tokyo, Japan.
Steven J AckermanDepartment of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois, Chicago, IL USA.
Cem AkinHarvard Medical School, Brigham and Women's Hospital, Boston, MA USA.
Frederic ClaytonDepartment of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT USA.
Franco H FalconeThe School of Pharmacy, University of Nottingham, Nottingham, United Kingdom.
Gerald J GleichDepartment of Dermatology, University of Utah, School of Medicine, Salt Lake City, UT USA.
Anne-Marie IraniVirginia Commonwealth University, Children's Hospital of Richmond, Richmond, VA USA.
Mats W JohanssonDepartment of Biomolecular Chemistry, University of Wisconsin, Madison, WI USA.
Amy D KlionHuman Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD USA.
Kristin M LeifermanUniversity of Utah, Salt Lake City, UT USA.
Francesca Levi-SchafferThe Hebrew University of Jerusalem, Jerusalem, Israel.
Gunnar NilssonClinical Immunology and Allergy, Department of Medicine, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
Yoshimichi OkayamaAllergy and Immunology Group, Research Institute of Medical Science, Nihon University Graduate School of Medicine, Tokyo, Japan.
Calman PrussinLaboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 USA.
John T SchroederDivision of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA.
Lawrence B SchwartzVirginia Commonwealth University, Richmond, VA USA.
Hans-Uwe SimonUniversity of Bern, Institute of Pharmacology, Bern, Switzerland.
Andrew F WallsSouthampton General Hospital, Immunopharmacology Group, Southampton, Hampshire UK.
Massimo TriggianiDivision of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy.
National Institutes of Health · USUniversity of Utah · USVirginia Commonwealth University · USHarvard University · USHebrew University of Jerusalem · ILJohns Hopkins Medicine · USKarolinska Institutet · SENihon University · JPNippon Medical School · JPSouthampton General Hospital · GBUniversity of Bern · CHUniversity of Illinois Chicago · USUniversity of Nottingham · GBUniversity of Salerno · ITUniversity of Wisconsin–Madison · US

Funding

Eosinophils and Eosinophil Activation in the Pathogenesis of Human DiseaseZIAAI001130 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KLION, AMY · 2010 to 2025
$22.5M
Thr Role of Pin1 in AirwayP01HL088594 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI JARJOUR, NIZAR N · 2008 to 2017
$21.0M
The Pathogenesis, Diagnosis, And Treatment Of Systemic Mast Cell DisordersZIAAI000249 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KOMAROW, HIRSH D · 2009 to 2025
$16.5M
Pathogenesis and Treatment of Idiopathic AnaphylaxisZIAAI001092 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CARTER, MELODY C · 2009 to 2025
$10.8M
Integrated Signaling Pathways for the Enhancement of Mast Cell ActivationZIAAI000965 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI METCALFE, DEAN D · 2009 to 2018
$5.3M
Stability of Severe Asthma Phenotypes: Impact of ExacerbationsU10HL109168 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI JARJOUR, NIZAR N · 2011 to 2016
$3.9M
Human DC Subtypes in Regulating T-Helper-2 ResponsesR01AI115703 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SCHROEDER, JOHN T. · 2015 to 2019
$2.0M
Phase 2 Study of Esophageal String Test in Diagnosing Eosinophilic EsophagitisR01FD004086 · FDA · UNIVERSITY OF COLORADO DENVER · PI ACKERMAN, STEVEN JULES, FURUTA, GLENN T · 2013 to 2018
$1.6M
Peptide-based nanoparticle inhibition of CCR3-mediated inflammatory cell recruitmR21HL118588 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GAPONENKO, VADIM V · 2013 to 2014
$423k
Department of Health H039FDA HHS R01 FD004086Medical Research Council G0500729NHLBI NIH HHS P01 HL088594NHLBI NIH HHS R21 HL118588NHLBI NIH HHS U10 HL109168NIAID NIH HHS R01 AI115703
6 · The paper itself

Abstract

Biomarkers of disease activity have come into wide use in the study of mechanisms of human disease and in clinical medicine to both diagnose and predict disease course; as well as to monitor response to therapeutic intervention. Here we review biomarkers of the involvement of mast cells, basophils, and eosinophils in human allergic inflammation. Included are surface markers of cell activation as well as specific products of these inflammatory cells that implicate specific cell types in the inflammatory process and are of possible value in clinical research as well as within decisions made in the practice of allergy-immunology.

Identifiers

PMID26904159
PMCPMC4751725
OpenAlexW2267347745

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.