ArticleFrontiers in immunology2016
Peracetic Acid Treatment Generates Potent Inactivated Oral Vaccines from a Broad Range of Culturable Bacterial Species.
Article in Frontiers in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 54 citations in OpenAlex.
- Bifidobacterium pseudocatenulatum capsular exopolysaccharide enhances systemic anti-tumour immunity in pre-clinical breast cancer.Research square · 2026Article
- Phage-steering permits antibody-mediated clearance of E. coli K1 from the gut.Nature communications · 2026Article
- Vaccine-enhanced competition permits rational bacterial strain replacement in the gut.Science (New York, N.Y.) · 2025Article
- Comparative Evaluation of a Disinfectant Formulation Comprising Hydrogen Peroxide, Peracetic Acid, and Acetic Acid AgainstInternational journal of microbiology · 2025Article
- Emerging Strategies against Non-TyphoidalCurrent issues in molecular biology · 2024Review
- Again and Again-Survival ofPharmaceutics · 2024Article
- M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer's patch.Immunity · 2023Article
- Photometric determination of peracetic acid by reaction with potassium iodide solution.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2023Article
- Antibody diversity in IVIG: Therapeutic opportunities for novel immunotherapeutic drugs.Frontiers in immunology · 2023Review
- Intestinal colonization regulates systemic anti-commensal immune sensitivity and hyperreactivity.Frontiers in immunology · 2023Article
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- Diversity and dynamism of IgA-microbiota interactions.Nature reviews. Immunology · 2021Review
- Final Endodontic Irrigation with 2% Peracetic Acid: Antimicrobial Activity and Cytotoxicity.European journal of dentistry · 2021Article
- A rationally designed oral vaccine induces immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants.Nature microbiology · 2021Article
- Evolutionary causes and consequences of bacterial antibiotic persistence.Nature reviews. Microbiology · 2020Review
- Uncoupling of invasive bacterial mucosal immunogenicity from pathogenicity.Nature communications · 2020Article
- Growing, evolving and sticking in a flowing environment: understanding IgA interactions with bacteria in the gut.Immunology · 2020Review
- IgA and the intestinal microbiota: the importance of being specific.Mucosal immunology · 2020Review
- ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens.Nature communications · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Our mucosal surfaces are the main sites of non-vector-borne pathogen entry, as well as the main interface with our commensal microbiota. We are still only beginning to understand how mucosal adaptive immunity interacts with commensal and pathogenic microbes to influence factors such as infectivity, phenotypic diversity, and within-host evolution. This is in part due to difficulties in generating specific mucosal adaptive immune responses without disrupting the mucosal microbial ecosystem itself. Here, we present a very simple tool to generate inactivated mucosal vaccines from a broad range of culturable bacteria. Oral gavage of 10(10) peracetic acid-inactivated bacteria induces high-titer-specific intestinal IgA in the absence of any measurable inflammation or species invasion. As a proof of principle, we demonstrate that this technique is sufficient to provide fully protective immunity in the murine model of invasive non-typhoidal Salmonellosis, even in the face of severe innate immune deficiency.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.