ReviewFrontiers in endocrinology2016
The Role of Dafachronic Acid Signaling in Development and Longevity in Caenorhabditis elegans: Digging Deeper Using Cutting-Edge Analytical Chemistry.
Review in Frontiers in endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Heterokairic Genes and the Eco-Evo-Devo of Timing.Evolution & development · 2026Review
- Host environment shapes filarial parasite fitness and Wolbachia endosymbionts dynamics.PLoS pathogens · 2025Article
- Filarial DAF-12 sense the host serum to resume iL3 development during infection.PLoS pathogens · 2023Article
- Characterization of Eight Bacterial Biosensors for Microbial Diagnostic and Therapeutic Applications.ACS synthetic biology · 2022Article
- Both entry to and exit from diapause arrest in Caenorhabditis elegans are regulated by a steroid hormone pathway.Development (Cambridge, England) · 2022Article
- Cytochromes P450 ofBiomolecules · 2022Review
- Degradation of Bile Acids by Soil and Water Bacteria.Microorganisms · 2021Review
- Quo VadisMetabolites · 2021Review
- Identification of a Novel Link between the Intermediate Filament Organizer IFO-1 and Cholesterol Metabolism in theInternational journal of molecular sciences · 2020Article
- A Molecular Basis for Reciprocal Regulation between Pheromones and Hormones in Response to Dietary Cues inInternational journal of molecular sciences · 2020Article
- A nematode sterol C4α-methyltransferase catalyzes a new methylation reaction responsible for sterol diversity.Journal of lipid research · 2020Article
- Mechanisms by which PE21, an extract from the white willowOncotarget · 2019Article
- The nutritional requirements ofGenes & nutrition · 2019Review
- The Dual Role of the Pervasive "Fattish" Tissue Remodeling With Age.Frontiers in endocrinology · 2019Review
- Halloween genes in panarthropods and the evolution of the early moulting pathway in Ecdysozoa.Royal Society open science · 2018Article
- Modeling Meets Metabolomics-The WormJam Consensus Model as Basis for Metabolic Studies in the Model OrganismFrontiers in molecular biosciences · 2018Article
- Mechanisms Underlying the Essential Role of Mitochondrial Membrane Lipids in Yeast Chronological Aging.Oxidative medicine and cellular longevity · 2017Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Steroid hormones regulate physiological processes in species ranging from plants to humans. A wide range of steroid hormones exist, and their contributions to processes, such as growth, reproduction, development, and aging, is almost always complex. Understanding the biosynthetic pathways that generate steroid hormones and the signaling pathways that mediate their effects is thus of fundamental importance. In this work, we review recent advances in (i) the biological role of steroid hormones in the roundworm Caenorhabditis elegans and (ii) the development of novel methods to facilitate the detection and identification of these molecules. Our current understanding of steroid signaling in this simple organism serves to illustrate the challenges we face moving forward. First, it seems clear that we have not yet identified all of the enzymes responsible for steroid biosynthesis and/or degradation. Second, perturbation of steroid signaling affects a wide range of phenotypes, and subtly different steroid molecules can have distinct effects. Finally, steroid hormone levels are critically important, and minute variations in quantity can profoundly impact a phenotype. Thus, it is imperative that we develop innovative analytical tools and combine them with cutting-edge approaches including comprehensive and highly selective liquid chromatography coupled to mass spectrometry based on new methods such as supercritical fluid chromatography coupled to mass spectrometry (SFC-MS) if we are to obtain a better understanding of the biological functions of steroid signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.