Evidence map›Paper›PMID 26903944›Full record

ArticleFrontiers in neurology2016

A Prospective Pilot Investigation of Brain Volume, White Matter Hyperintensities, and Hemorrhagic Lesions after Mild Traumatic Brain Injury.

Michael Jarrett, Roger Tam, Enedino Hernández-Torres, Nancy Martin, Warren Perera, Yinshan Zhao, Elham Shahinfard, Shiroy Dadachanji, Jack Taunton, David K B Li and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Michael JarrettUBC MRI Research Centre, University of British Columbia , Vancouver, BC , Canada.
Roger TamDepartment of Radiology, University of British Columbia, Vancouver, BC, Canada; Department of Radiology, University of British Columbia, Vancouver, BC, Canada.
Enedino Hernández-TorresUBC MRI Research Centre, University of British Columbia , Vancouver, BC , Canada.
Nancy MartinDepartment of Radiology, Richmond Hospital, Richmond, BC, Canada; Department of Radiology, Burnaby Hospital, Burnaby, BC, Canada; Department of Radiology, Delta Hospital, Delta, BC, Canada.
Warren PereraMedical Imaging Department, St Vincent's Hospital , Melbourne, VIC , Australia.
Yinshan ZhaoDivision of Neurology, Department of Medicine, University of British Columbia , Vancouver, BC , Canada.
Elham ShahinfardDivision of Neurology, Department of Medicine, University of British Columbia , Vancouver, BC , Canada.
Shiroy DadachanjiDivision of Sports Medicine, Faculty of Medicine, University of British Columbia , Vancouver, BC , Canada.
Jack TauntonDivision of Sports Medicine, Faculty of Medicine, University of British Columbia , Vancouver, BC , Canada.
David K B LiUBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada; Department of Radiology, University of British Columbia, Vancouver, BC, Canada; MS/MRI Research Group, University of British Columbia, Vancouver, BC, Canada.
Alexander RauscherUBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada; Division of Neurology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
University of British Columbia · CAUniversity of British Columbia Hospital · CARichmond Hospital · CASt Vincent's Hospital Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI) is among the most common neurological disorders. Hemorrhagic lesions and white matter hyperintensities (WMH) are radiological features associated with moderate and severe TBI. Brain volume reductions have also been observed during the months following injury. In concussion, no signs of injury are observed on conventional magnetic resonance imaging (MRI), which may be a true feature of concussion or merely due to the limited sensitivity of imaging techniques used so far. Moreover, it is not known whether volume reductions are due to the resolution of trauma-related edema or a true volume loss. Forty-five collegiate-level ice hockey players (20 females) and 15 controls (9 females), 40 players underwent 3-T MRI for hemorrhages [multi-echo susceptibility-weighted imaging (SWI)], WMH (three-dimensional fluid-attenuated inversion recovery), and brain volume at the beginning and the end of the hockey season. Concussed athletes underwent additional imaging and neuropsychological testing at 3 days, 2 weeks, and 2 months after injury. At the end of the hockey season, brain volume was reduced compared to controls by 0.32% (p < 0.034) in the whole cohort and by 0.26% (p < 0.09) in the concussed athletes. Two weeks and 2 months after concussion, brain volume was reduced by -0.08% (p = 0.027) and -0.23% (p = 0.035), respectively. In athletes, the WMH were significantly closer to the interface between gray matter and white matter compared to controls. No significant changes in the number of WMH over the duration of the study were found in athletes. No microhemorrhages were detected as a result of concussion or playing a season of ice hockey. We conclude that mild TBI does not lead to transient increases in brain volume and no new microbleeds or WMH are detectable after concussion. Brain volume reductions appear by 2 weeks after concussion and persist until at least 2 months after concussion. Brain volume is reduced between the beginning and the end of the ice hockey season.

Indexed as

brain volumeconcussionMRImTBIneuroimagingsusceptibility-weighted imagingwhite matter hyperintensities

Identifiers

PMID26903944
PMCPMC4751255
OpenAlexW2288294125

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.