Evidence map›Paper›PMID 26903875›Full record

ReviewFrontiers in physiology2016

Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Angiogenesis: Potencial Clinical Application.

Consuelo Merino-González, Felipe A Zuñiga, Carlos Escudero, Valeska Ormazabal, Camila Reyes, Estefanía Nova-Lamperti, Carlos Salomón, Claudio Aguayo

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 1 pooled it
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 1 synthesis or guideline pooled it, 244 citations in OpenAlex.

  1. Pooled it
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  14. Crosstalk between MSC-extracellular vesicles andFrontiers in pharmacology · 2025
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69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Consuelo Merino-GonzálezDepartment of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepción Concepción, Chile.
Felipe A ZuñigaDepartment of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepción Concepción, Chile.
Carlos EscuderoVascular Physiology Laboratory, Group of Investigation in Tumor Angiogenesis (GIANT), Department of Basic Sciences, Universidad del Bío-BíoChillán, Chile; Group of Research and Innovation in Vascular Health (GRIVAS Health)Chillán, Chile.
Valeska OrmazabalDepartment of Physiopathology, Faculty of Biological Sciences, University of Concepción Concepción, Chile.
Camila ReyesDepartment of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepción Concepción, Chile.
Estefanía Nova-LampertiMRC Centre for Transplantation, King's College London London, UK.
Carlos SalomónExosome Biology Laboratory, Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research, Royal Brisbane and Women's Hospital, The University of Queensland Brisbane, QLD, Australia.
Claudio AguayoDepartment of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of ConcepciónConcepción, Chile; Group of Research and Innovation in Vascular Health (GRIVAS Health)Chillán, Chile.
University of Concepción · CLKing's College London · GBUniversity of Bío-Bío · CLUniversity of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) are adult multipotent stem cells that are able to differentiate into multiple specialized cell types including osteocytes, adipocytes, and chondrocytes. MSCs exert different functions in the body and have recently been predicted to have a major clinical/therapeutic potential. However, the mechanisms of self-renewal and tissue regeneration are not completely understood. It has been shown that the biological effect depends mainly on its paracrine action. Furthermore, it has been reported that the secretion of soluble factors and the release of extracellular vesicles, such as exosomes, could mediate the cellular communication to induce cell-differentiation/self-renewal. This review provides an overview of MSC-derived exosomes in promoting angiogenicity and of the clinical relevance in a therapeutic approach.

Indexed as

angiogenesisextracellular vesiclesmesenchymal stem cell

Identifiers

PMID26903875
PMCPMC4746282
OpenAlexW2260555089

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.