Evidence map›Paper›PMID 26903857›Full record

ReviewFrontiers in aging neuroscience2016

Diagnostic Value of microRNA for Alzheimer's Disease: A Systematic Review and Meta-Analysis.

Yong-Bo Hu, Chun-Bo Li, Ning Song, Yang Zou, Sheng-Di Chen, Ru-Jing Ren, Gang Wang

Erratum issuedOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in aging neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 7 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 7 syntheses or guidelines pooled it, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Yong-Bo HuDepartment of Neurology, Neuroscience Institute, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China.
Chun-Bo LiShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine , Shanghai , China.
Ning SongSt George Hospital , Sydney, NSW , Australia.
Yang ZouDepartment of Neurology, Neuroscience Institute, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China.
Sheng-Di ChenDepartment of Neurology, Neuroscience Institute, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China.
Ru-Jing RenDepartment of Neurology, Neuroscience Institute, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China.
Gang WangDepartment of Neurology, Neuroscience Institute, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China.
Shanghai Jiao Tong University · CNRuijin Hospital · CNSt George Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sound evidence indicates that microRNAs (miRNAs) are aberrantly expressed in Alzheimer's disease (AD) patients. We performed a systematic review and meta-analysis to investigate the role of miRNA in AD pathogenesis and their clinical diagnostic value; a systematic review of literature and meta-analysis of clinical trials were performed. In the systematic review, 236 papers were included, and we reviewed the dysregulated miRNA expression in different parts of AD patients in order to identify the relationship between aberrantly expressed miRNAs and AD pathology. In the subsequent meta-analysis, seven studies were statistically analyzed with the following results: pooled sensitivity 0.86 (95%CI 0.79-0.90), pooled specificity 0.87 (95%CI 0.72-0.95), diagnostic odds ratio (28.29), and the area under the curve (0.87). In conclusion, our review indicated that aberrant expression of various miRNAs plays an important role in the pathological process of AD, and statistical analysis of quantitative studies reveal the potential value of specific miRNAs in the diagnosis of AD.

Indexed as

Alzheimer’s diseasediagnostic valuemeta-analysismiRNAsystematic review

Identifiers

PMID26903857
PMCPMC4746262
OpenAlexW2267966297

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.