Evidence map›Paper›PMID 26903799›Full record

ArticleFrontiers in neuroscience2015

ICU Blood Pressure Variability May Predict Nadir of Respiratory Depression After Coronary Artery Bypass Surgery.

Anne S M Costa, Paulo H M Costa, Carlos E B de Lima, Luiz E M Pádua, Luciana A Campos, Ovidiu C Baltatu

Registry-linked trialOpen access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02074371 (Perioperative Parameters to Predict Postoperative Respiratory Depression After Cardiac Surgery), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02074371 completednot on this map

Perioperative Parameters to Predict Postoperative Respiratory Depression After Cardiac Surgery

TypeobservationalSponsorOvidiu Constantin BaltatuRan2012 to 2012Enrolled44ConditionsCoronary Artery Disease
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Anne S M CostaCenter of Innovation, Technology and Education, Camilo Castelo Branco UniversitySao Jose dos Campos, Brazil; Health Sciences Center, State University of PiauiTeresina, Brazil.
Paulo H M CostaHospital Sao Marcos Teresina, Brazil.
Carlos E B de LimaHospital Sao MarcosTeresina, Brazil; Health Sciences Center, Federal University of PiauiTeresina, Brazil.
Luiz E M PáduaHealth Sciences Center, Federal University of Piaui Teresina, Brazil.
Luciana A CamposCenter of Innovation, Technology and Education, Camilo Castelo Branco University Sao Jose dos Campos, Brazil.
Ovidiu C BaltatuCenter of Innovation, Technology and Education, Camilo Castelo Branco University Sao Jose dos Campos, Brazil.
Universidade Brasil · BRUniversidade Federal do Piauí · BRUniversidade Estadual do Piau · BRUniversidade São Marcos · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesSurgical stress induces alterations on sympathovagal balance that can be determined through assessment of blood pressure variability. Coronary artery bypass graft surgery (CABG) is associated with postoperative respiratory depression. In this study we aimed at investigating ICU blood pressure variability and other perioperative parameters that could predict the nadir of postoperative respiratory function impairment.

methodsThis prospective observational study evaluated 44 coronary artery disease patients subjected to coronary artery bypass surgery (CABG) with cardiopulmonary bypass (CPB). At the ICU, mean arterial pressure (MAP) was monitored every 30 min for 3 days. MAP variability was evaluated through: standard deviation (SD), coefficient of variation (CV), variation independent of mean (VIM), and average successive variability (ASV). Respiratory function was assessed through maximal inspiratory (MIP) and expiratory (MEP) pressures and peak expiratory flow (PEF) determined 1 day before surgery and on the postoperative days 3rd to 7th. Intraoperative parameters (volume of cardioplegia, CPB duration, aortic cross-clamp time, number of grafts) were also monitored.

resultsSince, we aimed at studying patients without confounding effects of postoperative complications on respiratory function, we had enrolled a cohort of low risk EuroSCORE (European System for Cardiac Operative Risk Evaluation) with < 2. Respiratory parameters MIP, MEP, and PEF were significantly depressed for 4-5 days postoperatively. Of all MAP variability parameters, the ASV had a significant good positive Spearman correlation (rho coefficients ranging from 0.45 to 0.65, p < 0.01) with the 3-day nadir of PEF after cardiac surgery. Also, CV and VIM of MAP were significantly associated with nadir days of MEP and PEF. None of the intraoperative parameters had any correlation with the postoperative respiratory depression.

conclusionsVariability parameters ASV, CV, and VIM of the MAP monitored at ICU may have predictive value for the depression of respiratory function after cardiac surgery as determined by peak expiratory flow and maximal expiratory pressure. ClinicalTrials.gov Identifier: NCT02074371.

Indexed as

autonomic nervous systemblood pressure variabilityCABGICUperioperative parametersrespiratory function

Identifiers

PMID26903799
PMCPMC4750525
OpenAlexW2236163829

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.