ArticleMediators of inflammation2016
Decreased Interleukin-4 Release from the Neurons of the Locus Coeruleus in Response to Immobilization Stress.
Article in Mediators of inflammation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
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- Protective Properties of Marine Alkyl Glycerol Ethers in Chronic Stress.Marine drugs · 2023Article
- Regulatory role of cytokines on etiology of depression in animal models: their biological mechanisms and clinical implication with physical exercise.Journal of exercise rehabilitation · 2022Review
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- Microglial Inflammatory-Metabolic Pathways and Their Potential Therapeutic Implication in Major Depressive Disorder.Frontiers in psychiatry · 2022Review
- IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis.Science advances · 2021Article
- Antidepressant effect and neural mechanism ofAnimal cells and systems · 2020Article
- The role of neuroinflammation on pathogenesis of affective disorders.Journal of exercise rehabilitation · 2020Review
- Interleukin-4 signalling pathway underlies the anxiolytic effect induced by 3-deoxyadenosine.Psychopharmacology · 2019Article
- Curcumin Regulates Anti-Inflammatory Responses by JAK/STAT/SOCS Signaling Pathway in BV-2 Microglial Cells.Biology · 2019Article
- Distinguishing normal brain aging from the development of Alzheimer's disease: inflammation, insulin signaling and cognition.Neural regeneration research · 2018Review
- Neuroimmunology of the Interleukins 13 and 4.Brain sciences · 2016Article
- The role of the locus coeruleus in the generation of pathological anxiety.Brain and neuroscience advancesReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been demonstrated that immobilization (IMO) stress affects neuroimmune systems followed by alterations of physiology and behavior. Interleukin-4 (IL-4), an anti-inflammatory cytokine, is known to regulate inflammation caused by immune challenge but the effect of IMO on modulation of IL-4 expression in the brain has not been assessed yet. Here, it was demonstrated that IL-4 was produced by noradrenergic neurons in the locus coeruleus (LC) of the brain and release of IL-4 was reduced in response to IMO. It was observed that IMO groups were more anxious than nontreated groups. Acute IMO (2 h/day, once) stimulated secretion of plasma corticosterone and tyrosine hydroxylase (TH) in the LC whereas these increments were diminished in exposure to chronic stress (2 h/day, 21 consecutive days). Glucocorticoid receptor (GR), TH, and IL-4-expressing cells were localized in identical neurons of the LC, indicating that hypothalamic-pituitary-adrenal- (HPA-) axis and sympathetic-adrenal-medullary- (SAM-) axis might be involved in IL-4 secretion in the stress response. Accordingly, it was concluded that stress-induced decline of IL-4 concentration from LC neurons may be related to anxiety-like behavior and an inverse relationship exists between IL-4 secretion and HPA/SAM-axes activation.
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