ArticleProceedings of the National Academy of Sciences of the United States of America2016
Parallel computation with molecular-motor-propelled agents in nanofabricated networks.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Amplification of computational power by the multiplication of bacteria exploring microfluidic networks encoding mathematical problems.Microsystems & nanoengineering · 2026Article
- An Analysis of the Governance, Ethical, Legal, and Social Implications of Biocomputing.Science and engineering ethics · 2026Article
- Active spiralling of microtubules driven by kinesin motors.Scientific reports · 2025Article
- Microscope-Free Analyte Detection Based on Fiber-Optic Gliding Motility Assays.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Lowering Ionic Strength Improves the Sensitivity of Microtubule Gliding Assay Based Molecular Detection.Nano letters · 2025Article
- Barcoding Microtubules: Encoding Information onto Macromolecules by Photobleaching.Nano letters · 2025Article
- Improved longevity of actomyosin in vitro motility assays for sustainable lab-on-a-chip applications.Scientific reports · 2024Article
- Autonomous assembly and disassembly of gliding molecular robots regulated by a DNA-based molecular controller.Science advances · 2024Article
- Surface Topography Induces and Orients Nematic Swarms of Active Filaments: Considerations for Lab-On-A-Chip Devices.ACS applied nano materials · 2024Article
- Motility of an autonomous protein-based artificial motor that operates via a burnt-bridge principle.Nature communications · 2024Article
- Exploitation of Engineered Light-Switchable Myosin XI for Nanotechnological Applications.ACS nano · 2023Article
- Accounts of applied molecular rotors and rotary motors: recent advances.Nanoscale advances · 2023Review
- Fundamental energy cost of finite-time parallelizable computing.Nature communications · 2023Article
- Nanolithographic Fabrication Technologies for Network-Based Biocomputation Devices.Materials (Basel, Switzerland) · 2023Article
- Electro-detachment of kinesin motor domain from microtubule in silico.Computational and structural biotechnology journal · 2023Article
- Solving Exact Cover Instances with Molecular-Motor-Powered Network-Based Biocomputation.ACS nanoscience Au · 2022Article
- Through the Eyes of Creators: Observing Artificial Molecular Motors.ACS nanoscience Au · 2022Review
- Linking path and filament persistence lengths of microtubules gliding over kinesin.Scientific reports · 2022Article
- Nano/Micromotors in Active Matter.Micromachines · 2022Review
- Controlling the Rigidity of Kinesin-Propelled Microtubules in anACS omega · 2022Article
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10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The combinatorial nature of many important mathematical problems, including nondeterministic-polynomial-time (NP)-complete problems, places a severe limitation on the problem size that can be solved with conventional, sequentially operating electronic computers. There have been significant efforts in conceiving parallel-computation approaches in the past, for example: DNA computation, quantum computation, and microfluidics-based computation. However, these approaches have not proven, so far, to be scalable and practical from a fabrication and operational perspective. Here, we report the foundations of an alternative parallel-computation system in which a given combinatorial problem is encoded into a graphical, modular network that is embedded in a nanofabricated planar device. Exploring the network in a parallel fashion using a large number of independent, molecular-motor-propelled agents then solves the mathematical problem. This approach uses orders of magnitude less energy than conventional computers, thus addressing issues related to power consumption and heat dissipation. We provide a proof-of-concept demonstration of such a device by solving, in a parallel fashion, the small instance {2, 5, 9} of the subset sum problem, which is a benchmark NP-complete problem. Finally, we discuss the technical advances necessary to make our system scalable with presently available technology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.