ArticleProceedings of the National Academy of Sciences of the United States of America2016
Contrasting responses within a single neuron class enable sex-specific attraction in Caenorhabditis elegans.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 64 citations in OpenAlex.
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- Ciliary intrinsic mechanisms regulate dynamic ciliary extracellular vesicle release from sensory neurons.Current biology : CB · 2024Article
- C. elegans males optimize mate-preference decisions via sex-specific responses to multimodal sensory cues.Current biology : CB · 2024Article
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- Transcriptomic profiling of sex-specific olfactory neurons reveals subset-specific receptor expression in Caenorhabditis elegans.Genetics · 2023Article
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- Tracking N- and C-termini of C. elegans polycystin-1 reveals their distinct targeting requirements and functions in cilia and extracellular vesicles.PLoS genetics · 2022Article
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- Visualizing the organization and differentiation of the male-specific nervous system of C. elegans.Development (Cambridge, England) · 2021Article
- Distinct neuropeptide-receptor modules regulate a sex-specific behavioral response to a pheromone.Communications biology · 2021Article
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- Chemosensory signal transduction in Caenorhabditis elegans.Genetics · 2021Review
- Photoaffinity probes for nematode pheromone receptor identification.Organic & biomolecular chemistry · 2019Article
- Ascaroside Pheromones: Chemical Biology and Pleiotropic Neuronal Functions.International journal of molecular sciences · 2019Review
- Co-option of neurotransmitter signaling for inter-organismal communication in C. elegans.Nature communications · 2019Article
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9 authors at 6 institutions in 1 country.
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Abstract
Animals find mates and food, and avoid predators, by navigating to regions within a favorable range of available sensory cues. How are these ranges set and recognized? Here we show that male Caenorhabditis elegans exhibit strong concentration preferences for sex-specific small molecule cues secreted by hermaphrodites, and that these preferences emerge from the collective dynamics of a single male-specific class of neurons, the cephalic sensory neurons (CEMs). Within a single worm, CEM responses are dissimilar, not determined by anatomical classification and can be excitatory or inhibitory. Response kinetics vary by concentration, suggesting a mechanism for establishing preferences. CEM responses are enhanced in the absence of synaptic transmission, and worms with only one intact CEM show nonpreferential attraction to all concentrations of ascaroside for which CEM is the primary sensor, suggesting that synaptic modulation of CEM responses is necessary for establishing preferences. A heterogeneous concentration-dependent sensory representation thus appears to allow a single neural class to set behavioral preferences and recognize ranges of sensory cues.
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