ArticleProceedings of the National Academy of Sciences of the United States of America2016
Emergence of functional subnetworks in layer 2/3 cortex induced by sequential spikes in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Complicated architecture of cortical microcircuit: a comprehensive review.Anatomical science international · 2025Review
- Robust encoding of natural stimuli by neuronal response sequences in monkey visual cortex.Nature communications · 2023Article
- Microstimulation of sensory cortex engages natural sensory representations.Current biology : CB · 2023Article
- Article
- Creation of Neuronal Ensembles and Cell-Specific Homeostatic Plasticity through Chronic Sparse Optogenetic Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Unraveling the mysteries of dendritic spine dynamics: Five key principles shaping memory and cognition.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2023Article
- Excitatory-inhibitory balance modulates the formation and dynamics of neuronal assemblies in cortical networks.Science advances · 2021Article
- Global enhancement of cortical excitability following coactivation of large neuronal populations.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Advances in adaptive optics-based two-photon fluorescence microscopy for brain imaging.Lasers in medical science · 2020Review
- Review
- Training and Spontaneous Reinforcement of Neuronal Assemblies by Spike Timing Plasticity.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Probing Single SynapsesFrontiers in synaptic neuroscience · 2019Article
- S1 Employs Feature-Dependent Differential Selectivity of Single Cells and Distributed Patterns of Populations to Encode Mechanosensations.Frontiers in cellular neuroscience · 2019Article
- De novo synaptogenesis induced by GABA in the developing mouse cortex.Science (New York, N.Y.) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
During cortical circuit development in the mammalian brain, groups of excitatory neurons that receive similar sensory information form microcircuits. However, cellular mechanisms underlying cortical microcircuit development remain poorly understood. Here we implemented combined two-photon imaging and photolysis in vivo to monitor and manipulate neuronal activities to study the processes underlying activity-dependent circuit changes. We found that repeated triggering of spike trains in a randomly chosen group of layer 2/3 pyramidal neurons in the somatosensory cortex triggered long-term plasticity of circuits (LTPc), resulting in the increased probability that the selected neurons would fire when action potentials of individual neurons in the group were evoked. Significant firing pattern changes were observed more frequently in the selected group of neurons than in neighboring control neurons, and the induction was dependent on the time interval between spikes, N-methyl-D-aspartate (NMDA) receptor activation, and Calcium/calmodulin-dependent protein kinase II (CaMKII) activation. In addition, LTPc was associated with an increase of activity from a portion of neighboring neurons with different probabilities. Thus, our results demonstrate that the formation of functional microcircuits requires broad network changes and that its directionality is nonrandom, which may be a general feature of cortical circuit assembly in the mammalian cortex.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.