Evidence map›Paper›PMID 26903591›Full record

ArticleEuropean journal of endocrinology2016

Leptin secretory dynamics and associated disordered eating psychopathology across the weight spectrum.

Charumathi Baskaran, Kamryn T Eddy, Karen K Miller, Erinne Meenaghan, Madhusmita Misra, Elizabeth A Lawson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Charumathi BaskaranPediatric Endocrine UnitMassachusetts General Hospital for Children and Harvard Medical School, 101 Merrimac, Suite 615, Boston, Massachusetts 02114, USANeuroendocrine UnitEating Disorder Clinical Research ProgramMassachusetts General Hospital for Children and Harvard Medical School, Boston, Massachusetts, USA Pediatric Endocrine UnitMassachusetts General Hospital for Children and Harvard Medical School, 101 Merrimac, Suite 615, Boston, Massachusetts 02114, USANeuroendocrine UnitEating Disorder Clinical Research ProgramMassachusetts General Hospital for Children and Harvard Medical School, Boston, Massachusetts, USA cbaskaran@mgh.harvard.edu.
Kamryn T EddyPediatric Endocrine UnitMassachusetts General Hospital for Children and Harvard Medical School, 101 Merrimac, Suite 615, Boston, Massachusetts 02114, USANeuroendocrine UnitEating Disorder Clinical Research ProgramMassachusetts General Hospital for Children and Harvard Medical School, Boston, Massachusetts, USA.
Karen K MillerPediatric Endocrine UnitMassachusetts General Hospital for Children and Harvard Medical School, 101 Merrimac, Suite 615, Boston, Massachusetts 02114, USANeuroendocrine UnitEating Disorder Clinical Research ProgramMassachusetts General Hospital for Children and Harvard Medical School, Boston, Massachusetts, USA.
Erinne MeenaghanPediatric Endocrine UnitMassachusetts General Hospital for Children and Harvard Medical School, 101 Merrimac, Suite 615, Boston, Massachusetts 02114, USANeuroendocrine UnitEating Disorder Clinical Research ProgramMassachusetts General Hospital for Children and Harvard Medical School, Boston, Massachusetts, USA.
Madhusmita MisraPediatric Endocrine UnitMassachusetts General Hospital for Children and Harvard Medical School, 101 Merrimac, Suite 615, Boston, Massachusetts 02114, USANeuroendocrine UnitEating Disorder Clinical Research ProgramMassachusetts General Hospital for Children and Harvard Medical School, Boston, Massachusetts, USA Pediatric Endocrine UnitMassachusetts General Hospital for Children and Harvard Medical School, 101 Merrimac, Suite 615, Boston, Massachusetts 02114, USANeuroendocrine UnitEating Disorder Clinical Research ProgramMassachusetts General Hospital for Children and Harvard Medical School, Boston, Massachusetts, USA.
Elizabeth A LawsonPediatric Endocrine UnitMassachusetts General Hospital for Children and Harvard Medical School, 101 Merrimac, Suite 615, Boston, Massachusetts 02114, USANeuroendocrine UnitEating Disorder Clinical Research ProgramMassachusetts General Hospital for Children and Harvard Medical School, Boston, Massachusetts, USA.
Massachusetts General Hospital · USHarvard University · USBoston Children's Hospital · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
TRAINING PROGRAM IN ENDOCRINOLOGY AND DIABETEST32DK007028 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Karen K Miller · 1986 to 2026
$18.5M
Hormones/Genes in Women's Health: From Bench to BedsideK12HD051959 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLDSTEIN, JILL M, REXRODE, KATHRYN M · 2005 to 2023
$8.8M
Appetite-regulating Hormones and Neurocircuitry in Anorexia NervosaK23MH092560 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI LAWSON, ELIZABETH AUSTEN · 2011 to 2015
$935k
Bone Metabolism and Body Composition in Young AthletesK24HD071843 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI MISRA, MADHUSMITA · 2013 to 2017
$930k
NCRR NIH HHS UL1 RR025758NICHD NIH HHS K12 HD051959NICHD NIH HHS K24 HD071843NIDDK NIH HHS T32 DK007028NIMH NIH HHS K23 MH092560
6 · The paper itself

Abstract

objectiveLeptin secretory dynamics across the weight spectrum and their relationship with disordered eating psychopathology have not been studied. Our objective was to compare leptin secretory dynamics in 13 anorexia nervosa (AN), 12 overweight/obese (OB) and 12 normal-weight women using deconvolution analysis.

methodsIn this cross-sectional study conducted at a tertiary referral center, serum leptin levels were obtained every 20  min from 2000 to 0800  h. Dual energy X-ray absorptiometry was used to measure percent body fat. Disordered eating psychopathology was assessed by the Eating Disorders Examination-Questionnaire (EDE-Q) and the Eating Disorders Inventory-2 (EDI-2).

resultsThe groups differed for basal leptin secretion (BASAL) (P=0.02). Mean leptin pulse amplitude, pulse mass, total pulsatile secretion (TPS) and area under the curve (AUC) were significantly different between groups before and after adjustment for BASAL (P<0.0001 for all). Leptin AUC correlated strongly with TPS (r=0.97, P<0.0001) and less with BASAL (r=0.35, P=0.03). On multivariate analysis, only TPS was a significant predictor of leptin AUC (P<0.0001). TPS was inversely associated with most EDE-Q and EDI-2 parameters and the associations remained significant for EDE-Q eating concern (P=0.01), and EDI-2 asceticism, ineffectiveness and social insecurity (P<0.05) after adjusting for BASAL. These relationships were not significant when controlled for percent body fat.

conclusionSecretory dynamics of leptin differ across weight spectrum, with mean pulse amplitude, mean pulse mass and TPS being low in AN and high in OB. Pulsatile, rather than basal secretion, is the major contributor to leptin AUC. Decreased pulsatile leptin is associated with disordered eating psychopathology, possibly reflecting low percent body fat in AN.

Indexed as

AdiposityAdultAnorexia NervosaBody Mass IndexBody WeightCase-Control StudiesCross-Sectional StudiesFeeding and Eating DisordersFemaleHumansLeptinObesityOverweightThinnessYoung AdultLeptin

Identifiers

PMID26903591
PMCPMC4764871
OpenAlexW2283290356

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.