ArticleJournal of atherosclerosis and thrombosis2016
Endothelial and Metabolic Function Interactions in Overweight/Obese Children.
Article in Journal of atherosclerosis and thrombosis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- The role of metformin in treatment of weight gain associated with atypical antipsychotic treatment in children and adolescents: A systematic review and meta-analysis of randomized controlled trials.Frontiers in psychiatry · 2022Pooled it
- Childhood obesity, cardiovascular and liver health: a growing epidemic with age.World journal of pediatrics : WJP · 2020Pooled it
- Molecular Basis of Cardiomyopathies in Type 2 Diabetes.International journal of molecular sciences · 2024Review
- Lower adiponectin is associated with higher anthropometry and insulin resistance but not with low cardiorespiratory fitness in adolescents.Journal of endocrinological investigation · 2024Article
- Role of FGF21 and Leptin for the Diagnosis of Metabolic Health in Children with and without Obesity.Journal of personalized medicine · 2023Article
- Effects and individual response of continuous and interval training on adiponectin concentration, cardiometabolic risk factors, and physical fitness in overweight adolescents.European journal of pediatrics · 2023Article
- Is early or late biological maturation trigger obesity? A machine learning modeling research in Turkey boys and girls.Frontiers in nutrition · 2023Article
- The Cardiovascular Disease (CVD) Risk Continuum from Prenatal Life to Adulthood: A Literature Review.International journal of environmental research and public health · 2022Review
- T-Cadherin and the Ratio of Its Ligands as Predictors of Carotid Atherosclerosis: A Pilot Study.Biomedicines · 2021Article
- Cardiovascular Risk Factors in Children with Obesity, Preventive Diagnostics and Possible Interventions.Metabolites · 2021Review
- Venous Thromboembolism in Children: From Diagnosis to Management.International journal of environmental research and public health · 2020Review
- Shedding "LIGHT" on the Link between Bone and Fat in Obese Children and Adolescents.International journal of molecular sciences · 2020Article
- Cardiovascular Implications in Idiopathic and Syndromic Obesity in Childhood: An Update.Frontiers in endocrinology · 2020Review
- Cardiovascular dysfunction and vitamin D status in childhood acute lymphoblastic leukemia survivors.World journal of pediatrics : WJP · 2019Article
- Mechanisms Involved in Childhood Obesity-Related Bone Fragility.Frontiers in endocrinology · 2019Review
- Children and Adolescents Macrovascular Reactivity Level and Dynamics, But Not the Microvascular Response, is Associated with Body Mass Index and Arterial Stiffness Levels.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2017Article
- Flow Mediated Dilatation as a Biomarker in Vascular Surgery Research.Journal of atherosclerosis and thrombosis · 2017Review
- Reduced circulating adiponectin levels are associated with the metabolic syndrome independently of obesity, lipid indices and serum insulin levels: a cross-sectional study.Lipids in health and disease · 2016Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimAlthough the underlined mechanisms are still unknown, metabolic/coagulation alterations related to childhood obesity can induce vascular impairments. The aim of this study was to investigate the relationship between metabolic/coagulation parameters and endothelial function/vascular morphology in overweight/obese children.
methodsThirty-five obese/overweight children (22 pre-pubertal, mean age: 9.52±3.35 years) were enrolled. Body mass index (BMI), homeostasis model assessment index (HOMAIR), metabolic and coagulation parameters, [adiponectin, fibrinogen, high molecular weight adiponectin (HMW), endothelin-1, and vonWillebrand factor antigen] ultrasound early markers of atherosclerosis [flow-mediated dilatation (FMD), common carotid intima-media thickness (C-IMT), and anteroposterior diameter of infra-renal abdominal aorta (APAO)] were assessed.
resultsAPAO was related to anthropometric (age: r=0.520, p=0.001; height: r=0.679, p＜0.001; weight: r=0.548, p=0.001; BMI: r=0.607, p＜0.001; SBP: r=0.377, p=0.026) and metabolic (HOMAIR: r=0.357, p=0.035; HMW: r=－0.355, p=0.036) parameters. Age, height, and systolic blood pressure were positively related to increased C-IMT (r=0.352, p=0.038; r=0.356, p=0.036; r=0.346, p=0.042, respectively). FMD was not related to any clinical and biochemical characteristics of the pediatric population. Age, HOMAIR, fasting glucose levels, and HMW were independent predictors for APAO increase. Each unit decrease in HMW concentrations (1 μg/ml) induced a 0.065 mm increase in APAO.
conclusionHigh molecular weight adiponectin is related to cardiovascular risk in overweight/obese children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.