ArticleMolecular psychiatry2016
Predicting clinical outcome from reward circuitry function and white matter structure in behaviorally and emotionally dysregulated youth.
Article in Molecular psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Weighing the predictive role of neural factors for adolescent anhedonia in the presence of demographic and clinical factors.Journal of mood and anxiety disorders · 2025Article
- Stage 2 Registered Report: The Bidirectional Relationship Between Brain Features and the Dysregulation Profile: A Longitudinal, Multimodal Approach.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Article
- Development and validation of a nomogram to predict mortality risk in patients with ischemic heart disease.Frontiers in cardiovascular medicine · 2023Article
- Associations of maternal emotion regulation with child white matter connectivity in Black American mother-child dyads.Developmental psychobiology · 2022Article
- Factors Related to Perceived Stigma in Parents of Children and Adolescents in Outpatient Mental Healthcare.International journal of environmental research and public health · 2022Article
- A combined risk model for the multi-encompassing identification of heterogeneities of prognoses, biological pathway variations and immune states for sepsis patients.BMC anesthesiology · 2022Article
- Informing the study of suicidal thoughts and behaviors in distressed young adults: The use of a machine learning approach to identify neuroimaging, psychiatric, behavioral, and demographic correlates.Psychiatry research. Neuroimaging · 2021Article
- A specific neural substrate predicting current and future impulsivity in young adults.Molecular psychiatry · 2021Article
- Associations between different white matter properties and reward-based performance modulation.Brain structure & function · 2021Article
- Protocol for a machine learning algorithm predicting depressive disorders using the T1w/T2w ratio.MethodsX · 2021Article
- Aberrant levels of cortical myelin distinguish individuals with depressive disorders from healthy controls.NeuroImage. Clinical · 2021Article
- Factors related to parental pre-treatment motivation in outpatient child and adolescent mental health care.European child & adolescent psychiatry · 2020Article
- Fixel-Based Diffusion Magnetic Resonance Imaging Reveals Novel Associations Between White Matter Microstructure and Childhood Aggressive Behavior.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Cingulum-Callosal white-matter microstructure associated with emotional dysregulation in children: A diffusion tensor imaging study.NeuroImage. Clinical · 2020Article
- Structural connectivity and risk for anhedonia after trauma: A prospective study and replication.Journal of psychiatric research · 2019Article
- Neuroimaging Markers of Risk, Disease Expression, and Resilience to Bipolar Disorder.Current psychiatry reports · 2019Review
- Network changes associated with transdiagnostic depressive symptom improvement following cognitive behavioral therapy in MDD and PTSD.Molecular psychiatry · 2018Article
- Pathways to Neuroprediction: Opportunities and challenges to prediction of treatment response in depression.Current behavioral neuroscience reports · 2018Article
- Model selection and prediction of outcomes in recent onset schizophrenia patients who undergo cognitive training.Schizophrenia research. Cognition · 2018Article
- Towards understanding and acting on risk factors for developmental psychopathology.European child & adolescent psychiatry · 2018Article
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Authors and funding
26 authors.
Funding
Abstract
Behavioral and emotional dysregulation in childhood may be understood as prodromal to adult psychopathology. Additionally, there is a critical need to identify biomarkers reflecting underlying neuropathological processes that predict clinical/behavioral outcomes in youth. We aimed to identify such biomarkers in youth with behavioral and emotional dysregulation in the Longitudinal Assessment of Manic Symptoms (LAMS) study. We examined neuroimaging measures of function and white matter in the whole brain using 80 youth aged 14.0 (s.d.=2.0) from three clinical sites. Linear regression using the LASSO (Least Absolute Shrinkage and Selection Operator) method for variable selection was used to predict severity of future behavioral and emotional dysregulation measured by the Parent General Behavior Inventory-10 Item Mania Scale (PGBI-10M)) at a mean of 14.2 months follow-up after neuroimaging assessment. Neuroimaging measures, together with near-scan PGBI-10M, a score of manic behaviors, depressive behaviors and sex, explained 28% of the variance in follow-up PGBI-10M. Neuroimaging measures alone, after accounting for other identified predictors, explained ~1/3 of the explained variance, in follow-up PGBI-10M. Specifically, greater bilateral cingulum length predicted lower PGBI-10M at follow-up. Greater functional connectivity in parietal-subcortical reward circuitry predicted greater PGBI-10M at follow-up. For the first time, data suggest that multimodal neuroimaging measures of underlying neuropathologic processes account for over a third of the explained variance in clinical outcome in a large sample of behaviorally and emotionally dysregulated youth. This may be an important first step toward identifying neurobiological measures with the potential to act as novel targets for early detection and future therapeutic interventions.
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