Evidence map›Paper›PMID 26903267›Full record

SynthesisMolecular psychiatry2016

A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression.

D R Goldsmith, M H Rapaport, B J Miller

2 registry-linked trialsOpen access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Molecular psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 849 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
849citing papers in PubMed, 13 pooled it
42.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03878160 nacompletednot on this mapstarted 2018, after this paper: background citation

Mindfulness-Based Cognitive Therapy Delivered Via Group Videoconferencing for Acute Coronary Syndrome Patients With Elevated Depression Symptoms

TypeinterventionalSponsorMassachusetts General HospitalRan2018 to 2020Enrolled27ConditionsAcute Coronary Syndrome, Depression, Myocardial Infarction, Unstable AnginaArmsIndividual Interview
NCT06945627 active not recruitingnot on this mapstarted 2024, after this paper: background citation

Profiling Vulnerability and Resilience for Mental Illness Following Viral Infections: Translating Epidemiology to Deep-phenotyping

TypeobservationalSponsorSara PolettiRan2024 to 2027Enrolled408,551ConditionsSevere Mental Illness, Inflammation, Viral Infections, Mood DisordersArmsThis research doesn't involve any kind of intervention on the study participants
3 · Its place in the literature

Who cites it

849 citing papers in PubMed, 13 syntheses or guidelines pooled it, 1,621 citations in OpenAlex.

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  20. Major depressive disorder-alcohol use disorder comorbidity: diagnosis, mechanisms and treatment.European archives of psychiatry and clinical neuroscience · 2026
    Review

789 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

D R GoldsmithDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Emory University, Atlanta, GA, USA.
M H RapaportDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Emory University, Atlanta, GA, USA.
B J MillerDepartment of Psychiatry and Health Behavior, Augusta University, Augusta, GA, USA.
Emory University · USAugusta University · US

Funding

Emory Psychiatry Clinical Scientist Training Program (CSTP)R25MH101079 · NIMH · EMORY UNIVERSITY · PI GOLDSMITH, DAVID RYAN, MILLER, ANDREW H · 2014 to 2025
$1.9M
A Potential State and Relapse Predictive Marker in SchizophreniaK23MH098014 · NIMH · AUGUSTA UNIVERSITY · PI MILLER, BRIAN JAMES · 2012 to 2016
$921k
NIMH NIH HHS K23 MH098014NIMH NIH HHS R25 MH101079PHS HHS
6 · The paper itself

Abstract

Schizophrenia, bipolar disorder and major depressive disorder (MDD) have all been associated with aberrant blood cytokine levels; however, neither the pattern of cytokine alterations nor the impact of clinical status have been compared across disorders. We performed a meta-analysis of blood cytokines in acutely and chronically ill patients with these major psychiatric disorders. Articles were identified by searching the PubMed, PsycInfo and Web of Science, and the reference lists of these studies. Sixty-eight studies met the inclusion criteria (40 schizophrenia, 10 bipolar disorder and 18 MDD) for acutely ill patients. Forty-six studies met the inclusion criteria (18 schizophrenia, 16 bipolar disorder and 12 MDD) for chronically ill patients. Levels of two cytokines (interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)), one soluble cytokine receptor (sIL-2R), and one cytokine receptor antagonist (IL-1RA) were significantly increased in acutely ill patients with schizophrenia, bipolar mania and MDD compared with controls (P<0.01). Following treatment of the acute illness, IL-6 levels significantly decreased in both schizophrenia and MDD (P<0.01); sIL-2R levels increased in schizophrenia; and IL-1RA levels in bipolar mania decreased. In chronically ill patients, the levels of IL-6 were significantly increased in schizophrenia, euthymic (but not depressed) bipolar disorder and MDD compared with controls (P<0.01). The levels of IL-1β and sIL-2R were significantly increased in both chronic schizophrenia and euthymic bipolar disorder. Overall, there were similarities in the pattern of cytokine alterations in schizophrenia, bipolar disorder and MDD during acute and chronic phases of illness, raising the possibility of common underlying pathways for immune dysfunction. Effects of treatment on cytokines were more robust for schizophrenia and MDD, but were more frequently studied than for acute mania. These findings have important implications for our understanding of the pathophysiology and treatment of major psychiatric disorders.

Indexed as

AdultBipolar DisorderCytokinesDepressionFemaleHumansInterleukin 1 Receptor Antagonist ProteinInterleukin-6Major Depressive DisorderMalePsychotic DisordersReceptors, Interleukin-2SchizophreniaTumor Necrosis Factor-alphaCytokinesIL6 protein, humanInterleukin 1 Receptor Antagonist ProteinInterleukin-6Receptors, Interleukin-2Tumor Necrosis Factor-alpha

Identifiers

PMID26903267
PMCPMC6056174
OpenAlexW2399060753

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.