Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2016
Prevention of Depression in At-Risk Adolescents: Predictors and Moderators of Acute Effects.
Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00073671 (Prevention of Depression in At-Risk Adolescents), which is not on this map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevention of Depression in At-Risk Adolescents
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Genetics, epigenetics, and neurobiology of childhood-onset depression: an umbrella review.Molecular psychiatry · 2024Pooled it
- Family-Based Interventions for Youth Depression: Meta-Analysis of Randomized Clinical Trials.Child psychiatry and human development · 2023Pooled it
- Prevention programmes for children of parents with a mood/anxiety disorder: Systematic review of existing programmes and meta-analysis of their efficacy.The British journal of clinical psychology · 2021Pooled it
- Mediators of a randomized controlled trial of a preventive intervention for youth of parents with depressive disorders.Journal of consulting and clinical psychology · 2025Trial
- Cognitive and interpersonal moderators of two evidence-based depression prevention programs.Journal of consulting and clinical psychology · 2024Trial
- Indicated Prevention for Depression at the Transition to High School: Outcomes for Depression and Anxiety.Prevention science : the official journal of the Society for Prevention Research · 2019Trial
- Evaluating Effect Moderators in Cognitive Versus Behavioral Based CBT-Modules and Sequences Towards Preventing Adolescent Depression.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Trial
- Risk Factors for Development of New-onset Anxiety and Depression After Sports Medicine Surgeries in Patients 25 Years of Age or Younger.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026Article
- Relationship between circulating plasma endocannabinoids in adolescents and maternal depressive symptoms.Psychopharmacology · 2026Article
- Influence of the Big Five personality traits and the Wuxing of traditional Chinese medicine on depression in adolescents.Journal of education and health promotion · 2026Article
- Transdiagnostic prevention in youth mental health, Part II: interventions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- AMPK activation improves depression-like symptoms in olfactory bulbectomized mice by regulating microglia M1/M2 polarization in the hippocampus.Brain, behavior, & immunity - health · 2025Article
- Development and validation of a prediction model for the depressive symptom risk in commercial airline pilots.The EPMA journal · 2025Article
- Global trends of depressive disorders among women of reproductive age from 1990 to 2021: a systematic analysis of burden, sociodemographic disparities, and health workforce correlations.BMC psychiatry · 2025Article
- Mediating role of exercise in the relationship between body dissatisfaction and overeating using structural equation modeling.BMC public health · 2025Article
- Unraveling the complexities of adolescent depression: A call for action.World journal of psychiatry · 2024Article
- Characteristics and risk factors of Health-Related Risky behaviors in adolescents with Depression.Child and adolescent psychiatry and mental health · 2024Article
- Transcutaneous auricular vagus nerve stimulation ameliorates adolescent depressive- and anxiety-like behaviors via hippocampus glycolysis and inflammation response.CNS neuroscience & therapeutics · 2024Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
objectiveTo assess predictors and moderators of a cognitive-behavioral prevention (CBP) program for adolescent offspring of parents with depression.
methodThis 4-site randomized trial evaluated CBP compared to usual community care (UC) in 310 adolescents with familial (parental depression) and individual (youth history of depression or current subsyndromal symptoms) risk for depression. As previously reported by Garber and colleagues, a significant prevention effect favored CBP through 9 months; however, outcomes of CBP and UC did not significantly differ when parents were depressed at baseline. The current study expanded on these analyses and examined a range of demographic, clinical, and contextual characteristics of families as predictors and moderators and used recursive partitioning to construct a classification tree to organize clinical response subgroups.
resultsDepression onset was predicted by lower functioning (hazard ratio [HR] = 0.95, 95% CI = 0.92-0.98) and higher hopelessness (HR = 1.06, 95% CI = 1.01-1.11) in adolescents. The superior effect of CBP was diminished when parents were currently depressed at baseline (HR = 6.38, 95% CI = 2.38-17.1) or had a history of hypomania (HR = 67.5, 95% CI = 10.9-417.1), or when adolescents reported higher depressive symptoms (HR = 1.04, 95% CI = 1.00-1.08), higher anxiety (HR = 1.05, 95% CI = 1.01-1.08), higher hopelessness (HR = 1.10, 95% CI = 1.01-1.20), or lower functioning (HR = 0.94, 95% CI = 0.89-1.00) at baseline. Onset rates varied significantly by clinical response cluster (0%-57%).
conclusionDepression in adolescents can be prevented, but programs may produce superior effects when timed at moments of relative wellness in high-risk families. Future programs may be enhanced by targeting modifiable negative clinical indicators of response. CLINICAL TRIAL REGISTRATION INFORMATION: Prevention of Depression in At-Risk Adolescents; http://clinicaltrials.gov/; NCT00073671.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.