Evidence map›Paper›PMID 26903253›Full record

Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2016

A Randomized Clinical Trial of an Integrative Group Therapy for Children With Severe Mood Dysregulation.

James G Waxmonsky, Daniel A Waschbusch, Peter Belin, Tan Li, Lysett Babocsai, Hugh Humphery, Meaghan E Pariseau, Dara E Babinski, Martin T Hoffman, Jenifer L Haak and 5 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00632619 (A Novel Multimodal Intervention for Children With ADHD and Impaired Mood), which is not on this map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00632619 nacompletednot on this map

A Novel Multimodal Intervention for Children With ADHD and Impaired Mood

TypeinterventionalSponsorFlorida International UniversityRan2009 to 2011Enrolled68ConditionsAttention Deficit Disorder With HyperactivityArmsGroup-based behavior therapy, Stimulant medication therapy, Community-based psychosocial treatment
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.

  1. Pooled it
  2. The Status of Irritability in Psychiatry: A Conceptual and Quantitative Review.Journal of the American Academy of Child and Adolescent Psychiatry · 2016
    Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. An Exposure-Based Cognitive-Behavioral Therapy for Youth with Severe Irritability: Feasibility and Preliminary Efficacy.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
    Trial
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Network analysis of ecological momentary assessment identifies frustration as a central node in irritability.Journal of child psychology and psychiatry, and allied disciplines · 2023
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

James G WaxmonskyPenn State College of Medicine, Hershey, PA; Herbert Wertheim College of Medicine and the Center for Children and Families, Florida International University, Miami. Electronic address: jwaxmonsky@hmc.psu.edu.
Daniel A WaschbuschPenn State College of Medicine.
Peter BelinHerbert Wertheim College of Medicine and the Center for Children and Families, Florida International University.
Tan LiRobert Stempel College of Public Health and Social Work, Florida International University.
Lysett BabocsaiHerbert Wertheim College of Medicine and the Center for Children and Families, Florida International University.
Hugh HumpheryHerbert Wertheim College of Medicine and the Center for Children and Families, Florida International University.
Meaghan E PariseauCounseling, School and Educational Psychology, SUNY Buffalo, Buffalo, NY.
Dara E BabinskiPenn State College of Medicine.
Martin T HoffmanSUNY Buffalo School of Medicine.
Jenifer L HaakSUNY Buffalo School of Medicine.
Jessica R MazzantCenter for Children and Families, Florida International University.
Gregory A FabianoCounseling, School and Educational Psychology, SUNY Buffalo, Buffalo, NY.
Jeremy W PettitCenter for Children and Families, Florida International University.
Negar FallahazadRobert Stempel College of Public Health and Social Work, Florida International University.
William E PelhamCenter for Children and Families, Florida International University.
Florida International University · USUniversity at Buffalo, State University of New York · USCenter for Children · USFlorida Department of Children and Families · USPennsylvania State University · USPenn State Milton S. Hershey Medical Center · US

Funding

Career Development Program in Women's Health Research at Penn StateK12HD055882 · NICHD · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI WEISMAN, CAROL S · 2007 to 2016
$4.7M
A Novel Multimodal Intervention for Children with ADHD and Impaired MoodR34MH080791 · NIMH · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI WAXMONSKY, JAMES GAIER · 2008 to 2010
$628k
NICHD NIH HHS K12 HD055882NIMH NIH HHS MH080791NIMH NIH HHS R34 MH080791
6 · The paper itself

Abstract

objectiveNonepisodic irritability is a common and impairing problem, leading to the development of the diagnoses severe mood dysregulation (SMD) and disruptive mood dysregulation disorder (DMDD). No psychosocial therapies have been formally evaluated for either, with medication being the most common treatment. This study examined the feasibility and efficacy of a joint parent-child intervention for SMD.

methodA total of 68 participants aged 7 to 12 years with attention-deficit/hyperactivity disorder (ADHD) and SMD were randomly assigned to the 11-week therapy or community-based psychosocial treatment. All participants were first stabilized on psychostimulant medication by study physicians. Of the participants, 56 still manifested impairing SMD symptoms and entered the therapy phase. Masked evaluators assessed participants at baseline, midpoint, and endpoint, with therapy participants reassessed 6 weeks later.

resultsAll but 2 therapy participants attended the majority of sessions (n = 29), with families reporting high levels of satisfaction. The primary outcome of change in mood symptoms using the Mood Severity Index (MSI) did not reach significance except in the subset attending the majority of sessions (effect size = 0.53). Therapy was associated with significantly greater improvement in parent-rated irritability (effect size = 0.63). Treatment effects for irritability but not MSI diminished after therapy stopped. Little impact on ADHD symptoms was seen. Results may not be generalizable to youth with SMD and comorbidities different from those seen in this sample of children with ADHD, and are limited by the lack of a gold standard for measuring change in SMD symptoms.

conclusionWhile failing to significantly improve mood symptoms versus community treatment, the integrative therapy was found to be a feasible and efficacious treatment for irritability in participants with SMD and ADHD. CLINICAL TRIAL REGISTRATION INFORMATION: Group-Based Behavioral Therapy Combined With Stimulant Medication for Treating Children With Attention Deficit Hyperactivity Disorder and Impaired Mood; http://clinicaltrials.gov/; NCT00632619.

Indexed as

Behavior TherapyChildFemaleHumansMaleMood DisordersParent-Child RelationsPsychotherapy, GroupTreatment OutcomeADHDdisruptive mood dysregulation disordergroup therapypsychosocial treatmentsevere mood dysregulation

Identifiers

PMID26903253
PMCPMC4764804
OpenAlexW2221413780

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.