Evidence map›Paper›PMID 26903252›Full record

ArticleJournal of the American Academy of Child and Adolescent Psychiatry2016

Enhanced Social Attention in Female Infant Siblings at Risk for Autism.

Katarzyna Chawarska, Suzanne Macari, Kelly Powell, Lauren DiNicola, Frederick Shic

Abstract read
In one paragraph

Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 5 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 5 syntheses or guidelines pooled it, 94 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Atypicality of the N170 Event-Related Potential in Autism Spectrum Disorder: A Meta-analysis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018
    Pooled it
  5. Meta-Analysis of the RDoC Social Processing Domain across Units of Analysis in Children and Adolescents.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
    Pooled it
  6. Article
  7. Relations Between Preferential Looking to Synchronous Audiovisual Speech and Expressive Language in Infants With Autistic and Non-Autistic Siblings.Mind, brain and education : the official journal of the International Mind, Brain, and Education Society · 2026
    Article
  8. Narrative Ability in Autism and First-Degree Relatives.Journal of autism and developmental disorders · 2025
    Article
  9. Article
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  13. Article
  14. Family history of psychiatric conditions and development of siblings of children with autism.Autism research : official journal of the International Society for Autism Research · 2024
    Article
  15. Mid-childhood autism sibling recurrence in infants with a family history of autism.Autism research : official journal of the International Society for Autism Research · 2024
    Article
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  20. Distinct social attention profiles in preschoolers with autism contrasted to fragile X syndrome.Autism research : official journal of the International Society for Autism Research · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Katarzyna ChawarskaChild Study Center, Yale University School of Medicine, New Haven, CT. Electronic address: Katarzyna.Chawarska@yale.edu.
Suzanne MacariChild Study Center, Yale University School of Medicine, New Haven, CT.
Kelly PowellChild Study Center, Yale University School of Medicine, New Haven, CT.
Lauren DiNicolaChild Study Center, Yale University School of Medicine, New Haven, CT.
Frederick ShicChild Study Center, Yale University School of Medicine, New Haven, CT.
Yale University · US

Funding

TOURETTE'S SYNDROME &RELATED DISORDERS: STUDY OF HIGH DENSITY FAMILIESP01HD003008 · NICHD · YALE UNIVERSITY · PI VOLKMAR, FRED ROBERT · 1985 to 2010
$12.1M
Development of Face Processing in Infants with Autism Spectrum DisordersR01MH087554 · NIMH · YALE UNIVERSITY · PI CHAWARSKA, KATARZYNA · 2010 to 2014
$2.0M
NICHD NIH HHS P01 HD003008NIMH NIH HHS R01 MH087554
6 · The paper itself

Abstract

objectiveSexual dimorphism in autism spectrum disorders (ASD) is a well-recognized but poorly understood phenomenon. Females are four times less likely to be diagnosed with ASD than males and, when diagnosed, are more likely to exhibit comorbid anxiety symptoms. One of the key phenotypic features of ASD is atypical attention to socially relevant stimuli. Eye-tracking studies indicate atypical patterns of spontaneous social orienting during the prodromal and early syndromic stages of ASD. However, there have been no studies evaluating sex differences in early social orienting and their potential contribution to later outcomes.

methodWe examined sex differences in social orienting in 6-, 9-, and 12-month-old infants at high genetic risk for ASD (n = 101) and in low-risk controls (n = 61), focusing on neurobehavioral measures of function across a spectrum of autism risk.

resultsResults suggest that, between 6 and 12 months of age, a period highly consequential for the development of nonverbal social engagement competencies, high-risk females show enhanced attention to social targets, including faces, compared to both high-risk males and low-risk males and females. Greater attention to social targets in high-risk infants was associated with less severe social impairments at 2 years.

conclusionThe results suggest an alternative expression of autism risk in females, which manifests in infancy as increased attention toward socially relevant stimuli. This increased attention may serve as a female protective factor against ASD by providing increased access to social experiences in early development.

Indexed as

AttentionAutism Spectrum DisorderEye MovementsFemaleGenetic Predisposition to DiseaseHumansInfantMaleOrientationPhenotypeRisk FactorsSex FactorsSiblingsSocial Behaviorattentionautisminfancyprotective factorssex differences

Identifiers

PMID26903252
PMCPMC5812780
OpenAlexW2211975889

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.