ReviewJournal of the American Academy of Child and Adolescent Psychiatry2016
Prospective Longitudinal Studies of Infant Siblings of Children With Autism: Lessons Learned and Future Directions.
Review in Journal of the American Academy of Child and Adolescent Psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
129 citing papers in PubMed, 5 syntheses or guidelines pooled it, 247 citations in OpenAlex.
- Efficacy of very early interventions on neurodevelopmental outcomes for infants and toddlers at increased likelihood of or diagnosed with autism: A systematic review and meta-analysis.Autism research : official journal of the International Society for Autism Research · 2023Pooled it
- Pooled it
- Research Review: Outcomes of 24- to 36-month-old children with autism spectrum disorder vary by ascertainment strategy: a systematic review and meta-analysis.Journal of child psychology and psychiatry, and allied disciplines · 2020Pooled it
- Functioning Among Typically Developing Siblings of Individuals with Autism Spectrum Disorder: A Meta-Analysis.Clinical child and family psychology review · 2019Pooled it
- Pooled it
- Estimated Therapy Costs and Downstream Cost Consequences of iBASIS-Video Interaction to Promote Positive Parenting Intervention vs Usual Care Among Children Displaying Early Behavioral Signs of Autism in Australia.JAMA network open · 2023Trial
- Randomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years.Journal of child psychology and psychiatry, and allied disciplines · 2017Trial
- Toddler Screen Time: Longitudinal Associations with Autism and ADHD Symptoms and Developmental Outcomes.Child psychiatry and human development · 2026Article
- Clinical Features in Children With Loss of Autism Diagnosis and Persistent Autism: A Comparative Study.Journal of autism and developmental disorders · 2026Article
- Article
- Short-term outcomes and six-month follow-up of BEAR: a blended, pre-emptive intervention for infants and toddlers at elevated likelihood for autism.European child & adolescent psychiatry · 2026Article
- Distinct Temporal Stages of Infant Brain Processing Associate With Early Versus Later Autism Diagnosis.Developmental science · 2026Article
- Developmental Trajectories of Autistic Traits in Infants With Autism and/or ADHD Family History: Predictors and Mid-Childhood Outcomes.Journal of autism and developmental disorders · 2026Article
- Patterns of Early Development in Children with ADHD.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 · 2026Article
- Computerized Adaptive Tests for Rapid and Accurate Assessment of Autism.JAMA network open · 2026Article
- Analytical Validation of an ELISA Assay for Maternal Autoantibody-Related Autism.Diagnostics (Basel, Switzerland) · 2026Article
- Decreased attention in 10- and 14-month-olds with neurofibromatosis type 1 and association with later ADHD traits.Journal of neurodevelopmental disorders · 2026Article
- Theta Power at 10 Months of Age Predicts Developmental Change in Language in Infants With and Without an Elevated Likelihood for Autism.Developmental science · 2026Article
- Growth Trajectories of Joint Attention and Play as Predictors for Language in Young Children at Elevated Likelihood for Autism.Journal of autism and developmental disorders · 2026Article
- Functional Connectivity of the Neonatal Cerebellum is Impacted by Sex and Polygenic Liability for Autism.medRxiv : the preprint server for health sciences · 2026Article
69 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 8 institutions in 2 countries.
Funding
Abstract
objectiveThe objectives of this review are to highlight the impact of the first decade of high-risk (HR) infant sibling work in autism spectrum disorder (ASD) and to identify potential areas of translational focus for the next decade of research.
methodA group of clinicians and researchers in ASD working both inside and outside of the HR design met on a regular basis to review the infant sibling research, and came to an agreement on areas that had changed clinical practice and areas that had the potential to change practice with further research. The group then outlined several methodological and translational challenges that must be addressed in the next decade of research if the field is to reach its potential.
resultsThe review concluded that the HR design has yielded an understanding that ASD often, but not always, begins to emerge between 6 and 18 months, with early signs affecting social communication. Research using the HR design has also allowed a better understanding of the sibling recurrence risk (between 10% and 20%). Emerging areas of interest include the developmental trajectories of social communications skills in the early years, the expression of a milder phenotype in siblings not affected with ASD, and the possibility that early intervention with infant siblings may improve outcomes for those with ASD. Important challenges for the future include linking screening to intervention, collecting large sample sizes while ensuring cross-site reliability, and building in capacity for replication.
conclusionAlthough there are significant methodological and translational challenges for high-risk infant sibling research, the potential of this design to improve long-term outcomes of all children with ASD is substantial.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.