Evidence map›Paper›PMID 26903238›Full record

Trial reportSchizophrenia bulletin2016

Intensive Auditory Cognitive Training Improves Verbal Memory in Adolescents and Young Adults at Clinical High Risk for Psychosis.

Rachel Loewy, Melissa Fisher, Danielle A Schlosser, Bruno Biagianti, Barbara Stuart, Daniel H Mathalon, Sophia Vinogradov

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Schizophrenia bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00655239 (Neuroscience-Guided Cognitive Remediation in Adolescents at Risk for Psychosis), which is not on this map. Cited by 56 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 8 pooled it
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00655239 nacompletednot on this map

Neuroscience-Guided Cognitive Remediation in Adolescents at Risk for Psychosis

TypeinterventionalSponsorUniversity of California, San FranciscoRan2008 to 2016Enrolled143ConditionsSchizophreniaArmsNeuroadaptive cognitive training, Computer games
3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 8 syntheses or guidelines pooled it, 94 citations in OpenAlex.

  1. European Psychiatric Association guidance on assessment of cognitive impairment in schizophrenia.European psychiatry : the journal of the Association of European Psychiatrists · 2022
    Pooled it
  2. Video games for people with schizophrenia.The Cochrane database of systematic reviews · 2021
    Pooled it
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  5. Interventions for prodromal stage of psychosis.The Cochrane database of systematic reviews · 2019
    Pooled it
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  15. Efference copy/corollary discharge function and targeted cognitive training in patients with schizophrenia.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2019
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  19. Neurophysiologic measures of target engagement predict response to auditory-based cognitive training in treatment refractory schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rachel LoewyDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA;
Melissa FisherDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA; Department of Psychiatry, San Francisco Department of Veterans Affairs Medical Center, San Francisco, CA.
Danielle A SchlosserDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA;
Bruno BiagiantiDepartment of Psychiatry, San Francisco Department of Veterans Affairs Medical Center, San Francisco, CA.
Barbara StuartDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA;
Daniel H MathalonDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA; Department of Psychiatry, San Francisco Department of Veterans Affairs Medical Center, San Francisco, CA.
Sophia VinogradovDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA; Department of Psychiatry, San Francisco Department of Veterans Affairs Medical Center, San Francisco, CA Sophia.vinogradov@ucsf.edu.
University of California, San Francisco · USSan Francisco VA Medical Center · US

Funding

Neuroscience-Guided Cognitive Remediation in Adolescents at Risk for PsychosisR01MH081051 · NIMH · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI VINOGRADOV, SOPHIA · 2008 to 2012
$2.4M
PRIME to Action: Enhancing Motivation in Recent Onset SchizophreniaK23MH097795 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SCHLOSSER, DANIELLE A. · 2013 to 2016
$704k
NIMH NIH HHS K23 MH097795NIMH NIH HHS R01 MH081051
6 · The paper itself

Abstract

objectiveIndividuals at clinical high risk (CHR) for psychosis demonstrate cognitive impairments that predict later psychotic transition and real-world functioning. Cognitive training has shown benefits in schizophrenia, but has not yet been adequately tested in the CHR population.

methodsIn this double-blind randomized controlled trial, CHR individuals (N = 83) were given laptop computers and trained at home on 40 hours of auditory processing-based exercises designed to target verbal learning and memory operations, or on computer games (CG). Participants were assessed with neurocognitive tests based on the Measurement and Treatment Research to Improve Cognition in Schizophrenia initiative (MATRICS) battery and rated on symptoms and functioning. Groups were compared before and after training using a mixed-effects model with restricted maximum likelihood estimation, given the high study attrition rate (42%).

resultsParticipants in the targeted cognitive training group showed a significant improvement in Verbal Memory compared to CG participants (effect size = 0.61). Positive and Total symptoms improved in both groups over time.

conclusionsCHR individuals showed patterns of training-induced cognitive improvement in verbal memory consistent with prior observations in schizophrenia. This is a particularly vulnerable domain in individuals at-risk for psychosis that predicts later functioning and psychotic transition. Ongoing follow-up of this cohort will assess the durability of training effects in CHR individuals, as well as the potential impact on symptoms and functioning over time. Clinical Trials Number: NCT00655239. URL: https://clinicaltrials.gov/ct2/show/NCT00655239?term=vinogradov&rank=5.

Indexed as

Outcome Assessment, Health CareAdolescentAdultAuditory PerceptionChildCognitive DysfunctionCognitive RemediationDouble-Blind MethodFemaleHumansMaleMemoryPsychotic DisordersSchizophreniaVerbal LearningYoung Adultcognitive remediationprodromeschizophrenia

Identifiers

PMID26903238
PMCPMC4960436
OpenAlexW2284035850

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.