ArticleScientific reports2016
Three-Dimensional Characterization of Mechanical Interactions between Endothelial Cells and Extracellular Matrix during Angiogenic Sprouting.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Recent advancements and future requirements in vascularization of cortical organoids.Frontiers in bioengineering and biotechnology · 2022Pooled it
- Mechanically Spatio-Chimeric Fibrin Assembly Enables Vascular-Integrated Muscle Reconstruction for Volumetric Muscle Loss Repair.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Guidance for 3D traction force microscopy today and in the next decade.Nature methods · 2026Review
- External mechanical loading overrules cell-cell mechanical communication in sprouting angiogenesis during early bone regeneration.PLoS computational biology · 2023Article
- Mechanical regulation of the early stages of angiogenesis.Journal of the Royal Society, Interface · 2022Review
- Bioprinted microvasculature: progressing from structure to function.Biofabrication · 2022Review
- Tissue Engineered Neurovascularization Strategies for Craniofacial Tissue Regeneration.ACS applied bio materials · 2022Review
- Mechanical Aspects of Angiogenesis.Cancers · 2021Review
- 3D Printing of Microgel Scaffolds with Tunable Void Fraction to Promote Cell Infiltration.Advanced healthcare materials · 2021Article
- Dynamic Endothelial Stalk Cell-Matrix Interactions Regulate Angiogenic Sprout Diameter.Frontiers in bioengineering and biotechnology · 2021Article
- A multiscale model of complex endothelial cell dynamics in early angiogenesis.PLoS computational biology · 2021Article
- Interactions at engineered graft-tissue interfaces: A review.APL bioengineering · 2020Review
- Materials for blood brain barrier modelingMaterials science & engineering. R, Reports : a review journal · 2020Article
- Article
- Myosin IIA-mediated forces regulate multicellular integrity during vascular sprouting.Molecular biology of the cell · 2019Article
- Imaging the Dynamic Interaction Between Sprouting Microvessels and the Extracellular Matrix.Frontiers in physiology · 2019Review
- 3D matrix-embedding inhibits cycloheximide-mediated sensitization to TNF-alpha-induced apoptosis of human endothelial cells.Journal of tissue engineering and regenerative medicine · 2018Article
- Mechanoreciprocity in cell migration.Nature cell biology · 2018Review
- Agent-based computational model of retinal angiogenesis simulates microvascular network morphology as a function of pericyte coverage.Microcirculation (New York, N.Y. : 1994) · 2017Article
- Advances in on-chip vascularization.Regenerative medicine · 2017Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the three-dimensional cell-extracellular matrix interactions of endothelial cells that form multicellular structures called sprouts. We analyzed the data collected in-situ from angiogenic sprouting experiments and identified the differentiated interaction behavior exhibited by the tip and stalk cells. Moreover, our analysis of the tip cell lamellipodia revealed the diversity in their interaction behavior under certain conditions (e.g., when the heading of a sprout is switched approximately between the long-axis direction of two different lamellipodia). This study marks the first time that new characteristics of such interactions have been identified with shape changes in the sprouts and the associated rearrangements of collagen fibers. Clear illustrations of such changes are depicted in three-dimensional views.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.