Evidence map›Paper›PMID 26902996›Full record

ArticleJournal of endocrinological investigation2016

Polymorphisms of the FTO and MTHFR genes and vascular, inflammatory and metabolic marker levels in postmenopausal women.

P Chedraui, F R Pérez-López, G S Escobar, J A Espinoza-Caicedo, M Montt-Guevara, A R Genazzani, T Simoncini, Research Group for the Omega Women’s Health Project

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. RNA methylation in vascular disease: a systematic review.Journal of cardiothoracic surgery · 2022
    Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Article
  7. RNA Modification by mOxidative medicine and cellular longevity · 2021
    Review
  8. A Genetic Association Study ofGalen medical journal · 2019
    Review
  9. Plausible relationship between homocysteine and obesity risk viaDiabetes, metabolic syndrome and obesity : targets and therapy · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

P ChedrauiInstitute of Biomedicine, Research Area for Women's Health, Facultad de Ciencias Médicas, Universidad Católica de Santiago de Guayaquil, PO BOX 09-01-4671, Guayaquil, Ecuador. peter.chedraui@cu.ucsg.edu.ec.
F R Pérez-LópezDepartment of Obstetrics and Gynecology, Facultad de Medicina, Lozano Blesa University Hospital, Universidad de Zaragoza, Zaragoza, Spain.
G S EscobarInstitute of Biomedicine, Research Area for Women's Health, Facultad de Ciencias Médicas, Universidad Católica de Santiago de Guayaquil, PO BOX 09-01-4671, Guayaquil, Ecuador.
J A Espinoza-CaicedoInstitute of Biomedicine, Research Area for Women's Health, Facultad de Ciencias Médicas, Universidad Católica de Santiago de Guayaquil, PO BOX 09-01-4671, Guayaquil, Ecuador.
M Montt-GuevaraDivision of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
A R GenazzaniDivision of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
T SimonciniDivision of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Research Group for the Omega Women’s Health Project
Universisdad Católica de Santiago de Guayaquil · ECUniversity of Pisa · ITUniversidad de Zaragoza · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the prevalence of three single nucleotide polymorphisms (SNPs) in postmenopausal women with and without the metabolic syndrome (METS) and to explore levels of circulating biomarkers of inflammation, vascular and metabolic dysfunction according to SNP genotypes.

methodsDNA was extracted from the whole blood of 192 natural postmenopausal women (40 to 65 years) screened for the METS and tested for three gene SNPs related to obesity: the fat mass obesity (FTO: rs9939609) and the methylenetetrahydrofolate reductase (MTHFR: C677T and A1298C). Blood levels of angiopoietin, IL-8, sFASL, IL-6, TNF-α, sCD40L, PAI-1, u-PA, leptin, adiponectin, resistin, ghrelin, visfatin, adipsin and insulin were measured in a subgroup, with and without the METS, using multiplex technology (n = 100) and compared according to SNP genotypes.

resultsGenotype frequency of the three studied SNPs did not differ in relation to the presence of the METS. However, genotypes CT+TT (C677T) and AT (rs9939609) were more prevalent in women with high triglyceride levels. Pooled sub-analysis (n = 100) found that median sCD40L and visfatin levels were higher in women with genotypes AT+TT (rs9939609) as compared to AA (1178 vs. 937.0 pg/mL and 0.93 vs. 0.43 ng/mL, respectively, p < 0.05).

conclusionTwo SNP genotypes related to obesity were more prevalent in women with abnormal triglyceride levels and two vascular and inflammatory serum markers were higher in relation to the rs9939609 SNP.

Indexed as

AdultAgedAlpha-Ketoglutarate-Dependent Dioxygenase FTOBiomarkersCase-Control StudiesFemaleHumansInflammationMetabolic SyndromeMethylenetetrahydrofolate Reductase (NADPH2)Middle AgedObesityPolymerase Chain ReactionPolymorphism, Single NucleotidePostmenopauseVascular DiseasesAlpha-Ketoglutarate-Dependent Dioxygenase FTOBiomarkersFTO protein, humanMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanFTOGenotypesMetabolic syndromeMTHFRPolymorphismsPostmenopausesCD40LVisfatin

Identifiers

PMID26902996
OpenAlexW2287827970

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.