SynthesisClinical research in cardiology : official journal of the German Cardiac Society2016
Pulse pressure as an independent predictor of stroke: a systematic review and a meta-analysis.
Synthesis in Clinical research in cardiology : official journal of the German Cardiac Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Retinal imaging for the assessment of stroke risk: a systematic review.Journal of neurology · 2024Pooled it
- Pooled it
- Effect of Intensive and Standard Lipid-Lowering Therapy on the Progression of Stroke in Patients With Coronary Artery Syndromes: A Meta-Analysis of Randomized Controlled Trials.Journal of cardiovascular pharmacology · 2020Pooled it
- Efficacy of a multidomain intervention in older adults with vascular risks: The Japan-Multimodal Intervention Trial for the Prevention of Dementia (J-MINT).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- Influence of baseline systolic blood pressure on the relationship between intensive blood pressure control and cardiovascular outcomes in the Systolic Blood Pressure Intervention Trial (SPRINT).Clinical research in cardiology : official journal of the German Cardiac Society · 2019Trial
- Gastrointestinal Bleeding Risk Associated With Pulse Pressure in Patients With Atrial Fibrillation: Retrospective Cohort Study.Journal of medical Internet research · 2026Article
- Prediction of stroke events in patients with type 2 diabetes mellitus by interpretable machine learning based on perivascular adipose tissue features: a multicenter cohort study.Quantitative imaging in medicine and surgery · 2026Article
- Pulse pressure and cardiometabolic disease progression: associations with incident multimorbidity and mortality in UK biobank.Frontiers in cardiovascular medicine · 2026Article
- Sleep disruption from inhalation of biomass smoke: a basis for coincident hypertension?Particle and fibre toxicology · 2025Article
- Plasma Protein Mediation of the Association Between Blood Pressure and Retinal Vascular Occlusion.Translational vision science & technology · 2025Observational
- Pulse pressure after thrombectomy predicts functional outcomes and mortality in acute ischemic stroke with large artery occlusion.Scientific reports · 2025Article
- Relationships between blood pressure indicators and fluid biomarkers of brain aging in functionally intact older adults.Alzheimer's research & therapy · 2025Article
- Article
- Pulse pressure level after acute ischemic stroke is associated with early neurological deterioration.Experimental and therapeutic medicine · 2024Article
- Hemodynamic changes in progressive cerebral infarction: An observational study based on blood pressure monitoring.Journal of clinical hypertension (Greenwich, Conn.) · 2024Observational
- Integration of the systemic inflammatory response index with pulse pressure enhances prognostication of cardiovascular mortality in the general population of the United States: insights from the NHANES database.Frontiers in cardiovascular medicine · 2024Article
- Ambient temperature variability and blood pressure in a prospective cohort of 50,000 Chinese adults.Journal of human hypertension · 2023Article
- Relationship between pulse pressure and body mass index in active-duty Royal Thai Army personnel in Thailand.BMC cardiovascular disorders · 2023Article
- Association between baseline pulse pressure and hospital mortality in non-traumatic subarachnoid hemorrhage patients: a retrospective cohort study.Frontiers in neurology · 2023Article
- High pulse pressure is associated with an increased risk of diabetes in females but not in males: a retrospective cohort study.Biology of sex differences · 2022Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent evidence suggests that pulse pressure (PP) is a strong cardiovascular diseases' risk factor. We systematically evaluated all relevant studies to determine whether PP can be used as an independent predictor of stroke and mortality. METHODS AND
resultsA meta-analysis was performed by searching the published literature using MEDLINE, Cochrane and Google Scholar databases up to December 15, 2015. We measured the effect size expressed by hazard ratio (HR) and 95 % confidence interval (95 % CI). Eleven publications were included in the analysis. Pooled results demonstrated that 10 mmHg increase in PP was associated with increased risk of stroke occurrence (pooled HR 1.046, 95 % CI 1.025-1.068, P < 0.001). Additionally, systolic blood pressure (SBP) (pooled HR 1.053, 95 % CI 1.033-1.073, P < 0.001) and diastolic blood pressure (DPB) (pooled HR 1.056, 95 % CI 1.038-1.074, P < 0.001) were found to be significant predictors for stroke. We did not find a significant association between PP and all-cause mortality (pooled HR 1.022, 95 % CI 0.983-1.063, P = 0.270). We found SBP (pooled HR 1.008, 95 % CI 1.002-1.014, P = 0.012), but not DBP (pooled HR 1.023, 95 % CI 0.964-1.085, P = 0.451) to be significantly associated with all-cause mortality.
conclusionsCurrent data confirms that PP is an independent risk factor for stroke but is not a predictor of mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.