ArticleUrology2016
Modeling Cryotherapy Ice Ball Dimensions and Isotherms in a Novel Gel-based Model to Determine Optimal Cryo-needle Configurations and Settings for Potential Use in Clinical Practice.
Article in Urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Cryoablation for early-stage invasive breast cancer: pathologic and imaging outcomes from the prospective FIRST trial.Breast cancer research : BCR · 2026Trial
- Dual-energy CT fusion imaging improves ice-ball visualization in bone during spinal cryoablation in porcine cadavers.European radiology experimental · 2026Article
- Image-Guided Adaptive Cryotherapy for Prostate Cancer Treatment.Annals of biomedical engineering · 2025Article
- Focal therapy for prostate cancer.Abdominal radiology (New York) · 2025Review
- Focal Therapy for Prostate Cancer: Recent Advances and Insights.Current oncology (Toronto, Ont.) · 2024Review
- Review
- Cryoablation with KCl Solution Enhances Necrosis and Apoptosis of HepG2 Liver Cancer Cells.Annals of biomedical engineering · 2024Article
- Investigation of Lung Cancer Cell Response to Cryoablation and Adjunctive Gemcitabine-Based Cryo-Chemotherapy Using the A549 Cell Line.Biomedicines · 2024Article
- Recent Advances in Minimally Invasive Management of Osteolytic Periacetabular Skeletal Metastases.Seminars in interventional radiology · 2024Review
- The Assessment of a Novel Endoscopic Ultrasound-Compatible Cryocatheter to Ablate Pancreatic Cancer.Biomedicines · 2024Article
- Measurement Analysis of Ice Ball Size during CT-Guided Cryoablation Procedures for Better Prediction of Final Ice Ball Size and Avoidance of Complications.The Indian journal of radiology & imaging · 2023Article
- An In Vitro Investigation into Cryoablation and Adjunctive Cryoablation/Chemotherapy Combination Therapy for the Treatment of Pancreatic Cancer Using the PANC-1 Cell Line.Biomedicines · 2022Article
- Hybrid Simulation and Planning Platform for Cryosurgery with Microsoft HoloLens.Sensors (Basel, Switzerland) · 2021Article
- The Impact of Placement Errors on the Tumor Coverage in MRI-Guided Focal Cryoablation of Prostate Cancer.Academic radiology · 2021Article
- Renal cryoablation - a practical guide for interventional radiologists.The British journal of radiology · 2021Review
- Percutaneous cryoablation in early stage hepatocellular carcinoma: analysis of local tumor progression factors.Diagnostic and interventional radiology (Ankara, Turkey) · 2020Article
- Investigation of Bladder Cancer Cell Response to Cryoablation and Adjunctive Cisplatin Based Cryo/Chemotherapy.Clinical research (Milpitas, Calif.) · 2020Article
- Breast Cancer Cryoablation: Assessment of the Impact of Fundamental Procedural Variables in an In Vitro Human Breast Cancer Model.Breast cancer : basic and clinical research · 2020Article
- GPU-based 3D iceball modeling for fast cryoablation simulation and planning.International journal of computer assisted radiology and surgery · 2019Article
- Use of MRI-Guided Biopsy for Selection and Follow-up of Men Undergoing Hemi-gland Cryoablation of Prostate Cancer.Urology · 2019Observational
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo gain a better understanding of ice ball dimensions and temperature isotherms relevant for cell kill when using combinations of cryo-needles we set out to answer 4 questions: (1) what type of cryo-needle? (2) how many needles? (3) best spatial configuration? and (4) correct duty cycle percentage?
methodsWe conducted laboratory experiments to monitor ice ball dimensions and create multi-needle planar isotherm maps for 17G and 10G cryo-needles using a novel multi-needle thermocouple fixture within gel at body temperature. We tested configurations of 1-4 cryo-needles at duty cycles of 20%-100% with 1-2.5 cm spacing.
resultsAnalysis of various combinations shows that a central core of ≤-40°C develops at a distance of ~1 cm around the cryo-needles. Temperature increases linearly from this point to the ice ball leading edge (0°C), which is a further ≈1 cm away. Thus, the -40°C isotherm is approximately 1 cm inside the leading edge of the ice ball. The optimum distance between cryo-needles was 1.5-2 cm, at duty cycle settings of 70%-100%. At distances further apart or with lower duty cycle settings, ice balls either had a central core >-40°C or had an hourglass shape.
conclusionIn answer to questions 1-3, tumor length, diameter, and shape will ultimately determine the number of needles and their configuration. However, we propose a conservative distance for cryo-needle placement between 1 and 1.5 cm should be adopted for clinical practice. In answer to question 4, using low duty cycle settings runs the risk of incomplete -40°C isotherm coverage of the tumor, and thus in routine practice we suggest that settings of 70%-100% are most appropriate.
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