ArticleScientific reports2016
Investigation on the effects of the atmospheric pressure plasma on wound healing in diabetic rats.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 118 citations in OpenAlex.
- Prospective, comparative clinical pilot study of cold atmospheric plasma device in the treatment of atopic dermatitis.Scientific reports · 2021Trial
- Assessment of the Impact of Cold Atmospheric Plasma Application on Wound Healing in Streptozotocin-Induced Diabetic Rats.Antioxidants (Basel, Switzerland) · 2026Article
- Medical gas plasma modifies Nrf2 signaling in diabetic wound healing.Journal of advanced research · 2026Article
- Combination of Cold Helium Plasma with Fluoride Varnish to Improve Enamel Surface Protection.Materials (Basel, Switzerland) · 2025Article
- Enhancing Tissue Integration and Reducing Inflammation in Silicone and Human Acellular Dermal Matrix Implants via Vacuum Plasma Treatment.International journal of molecular sciences · 2025Article
- Plasma-Activated Water Improve Wound Healing in Diabetic Rats by Influencing the Inflammatory and Remodelling Phase.International journal of molecular sciences · 2025Article
- The effect of cold plasma on the treatment of external otitis: an experimental study in rats.AMB Express · 2024Article
- Cold Atmospheric Pressure Plasma: A Growing Paradigm in Diabetic Wound Healing-Mechanism and Clinical Significance.International journal of molecular sciences · 2023Review
- A novel approach to expedite wound healing with plasma brush of cold flame.The Review of scientific instruments · 2023Article
- Article
- Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements.Cells · 2022Review
- Biophysical evaluation of treating adipose tissue-derived stem cells using non-thermal atmospheric pressure plasma.Scientific reports · 2022Article
- Cold plasma enamel surface treatment to increase fluoride varnish uptake.Scientific reports · 2022Article
- Treatment of Fungal-Infected Diabetic Wounds with Low Temperature Plasma.Biomedicines · 2021Article
- Medical gas plasma-stimulated wound healing: Evidence and mechanisms.Redox biology · 2021Review
- Gas Plasma-Augmented Wound Healing in Animal Models and Veterinary Medicine.Molecules (Basel, Switzerland) · 2021Review
- Non-thermal plasma promotes hair growth by improving the inter-follicular macroenvironment.RSC advances · 2021Article
- Non-thermal atmospheric pressure plasma activates Wnt/β-catenin signaling in dermal papilla cells.Scientific reports · 2021Article
- Non-thermal plasma application enhances the recovery of transected sciatic nerves in rats.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Argon Atmospheric Plasma Treatment Promotes Burn Healing by Stimulating Inflammation and Controlling the Redox State.Inflammation · 2020Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is estimated that 15 percent of individuals with diabetes mellitus suffer from diabetic ulcers worldwide. The aim of this study is to present a non-thermal atmospheric plasma treatment as a novel therapy for diabetic wounds. The plasma consists of ionized helium gas that is produced by a high-voltage (8 kV) and high-frequency (6 kHz) power supply. Diabetes was induced in rats via an intravascular injection of streptozotocin. The plasma was then introduced to artificial xerograph wounds in the rats for 10 minutes. Immunohistochemistry assays was performed to determine the level of transforming growth factor (TGF-β1) cytokine. The results showed a low healing rate in the diabetic wounds compared with the wound-healing rate in non-diabetic animals (P < 0.05). Moreover, the results noted that plasma enhanced the wound-healing rate in the non-diabetic rats (P < 0.05), and significant wound contraction occurred after the plasma treatment compared with untreated diabetic wounds (P < 0.05). Histological analyses revealed the formation of an epidermis layer, neovascularization and cell proliferation. The plasma treatment also resulted in the release of TGF-β1 cytokine from cells in the tissue medium. The findings of this study demonstrate the effect of plasma treatment for wound healing in diabetic rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.