Evidence map›Paper›PMID 26902617›Full record

ArticleSurgical endoscopy2016

Red cell distribution width is a novel biomarker that predicts excess body-mass index loss 1 year after laparoscopic Roux-en-Y gastric bypass.

Eric S Wise, Kyle M Hocking, Adam Weltz, Anna Uebele, Jose J Diaz, Stephen M Kavic, Mark D Kligman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgical endoscopy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Eric S WiseDepartment of Surgery, Vanderbilt University Medical Center, 1161 21st Ave S, MCN T2121, Nashville, TN, 37232-2730, USA. eric.s.wise@vanderbilt.edu.
Kyle M HockingDepartment of Surgery, Vanderbilt University Medical Center, 1161 21st Ave S, MCN T2121, Nashville, TN, 37232-2730, USA.
Adam WeltzDepartment of Surgery, University of Maryland Medical Center, Baltimore, MD, USA.
Anna UebeleDepartment of Surgery, University of Maryland Medical Center, Baltimore, MD, USA.
Jose J DiazDepartment of Surgery, University of Maryland Medical Center, Baltimore, MD, USA.
Stephen M KavicDepartment of Surgery, University of Maryland Medical Center, Baltimore, MD, USA.
Mark D KligmanDepartment of Surgery, University of Maryland Medical Center, Baltimore, MD, USA.
University of Maryland, Baltimore · USUniversity of Maryland Medical Center · USVanderbilt University Medical Center · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
NCATS NIH HHS UL1 TR000445
6 · The paper itself

Abstract

introductionBariatric surgery is the most effective method for producing sustained weight loss, improving obesity-associated comorbidities and reducing inflammation in the morbidly obese population. The red cell distribution width (RDW) is a novel marker of inflammation that is usually reported as part of a complete blood count. In this study, we tested our hypothesis that red cell distribution width might represent a novel biomarker predictive of excess body-mass index loss (EBMIL) following laparoscopic Roux-en-Y gastric bypass (LRYGB).

methodsFive hundred and forty-seven LRYGB patients included from a single institution were individually reviewed, noting both preoperative RDW and percent excess BMI loss at 6 months and 1 year post-LRYGB (%EBMIL180 and %EBMIL365, respectively). Bivariate and multivariate linear regression analysis was conducted between age, gender, initial body-mass index (BMI0) and RDW and each of the two endpoints, to assess the independence of RDW as a predictor of postoperative success.

resultsThe median RDW was 13.9 (13.3-14.6) %, and median EBMIL180 and EBMIL365 were 55.4 (45.2-66.7) % and 71.3 (58.9-87.8) %, respectively. After controlling for age, gender and BMI0, RDW was associated with %EBMIL365 (B = -1.4 [-2.8 to -0.002] %, P = .05), but not %EBMIL180 (B = -0.6 [-1.6 to 0.5] %, P = .30. Upon Kruskal-Wallis analysis, patients with a preoperative RDW > 15.0 % had significantly lower %EBMIL than those in the <13.0 % (P < .001) and 13.0-15.0 % (P < .01) strata.

conclusionsRDW is predictive of EBMIL at 1 year following LRYGB. This represents a novel preoperative biomarker that may provide clinically useful prognostic information.

Indexed as

Erythrocyte IndicesAdultBariatric SurgeryBiomarkersFemaleGastric BypassHumansLaparoscopyLeast-Squares AnalysisLinear ModelsMaleMiddle AgedMultivariate AnalysisObesity, MorbidPrognosisRetrospective StudiesBiomarkersBariatricsBiomarkersGastric bypassLaparoscopyOutcomes

Identifiers

PMID26902617
PMCPMC4993689
OpenAlexW2281165581

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.