ReviewSurgical endoscopy2016
Transanal endoscopic microsurgery for rectal cancer: T1 and beyond? An evidence-based review.
Review in Surgical endoscopy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Transanal endoscopic microsurgery versus radical resection for early-stage rectal cancer: a systematic review and meta- analysis.International journal of colorectal disease · 2023Pooled it
- Neoadjuvant Chemotherapy, Excision, and Observation for Early Rectal Cancer: The Phase II NEO Trial (CCTG CO.28) Primary End Point Results.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023Trial
- Local excision in rectal cancer: When and for whom?World journal of gastrointestinal oncology · 2025Article
- Endoscopic mesorectal dissection for precise rectal cancer staging: trespassing the boundaries of lumenal rectal interventions.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2025Article
- Long-Term Outcomes of Patients with Poor Prognostic Factors Following Transanal Endoscopic Microsurgery (TEMS) for Early Rectal Cancer.Biomedicines · 2025Article
- Surgeon assessment of significant rectal polyps using white light endoscopy alone and in comparison to fluorescence-augmented AI lesion classification.Langenbeck's archives of surgery · 2024Article
- Lymph node metastasis in T1-2 colorectal cancer: a population-based study.International journal of colorectal disease · 2023Article
- Transanal endoscopic microsurgery after the attempt of endoscopic removal of rectal polyps.Surgical endoscopy · 2022Article
- Implementation of transanal minimally invasive surgery (TAMIS) for rectal neoplasms: results from a single centre.Techniques in coloproctology · 2022Article
- Prognosis of Patients Over 60 Years Old With Early Rectal Cancer Undergoing Transanal Endoscopic Microsurgery - A Single-Center Experience.Frontiers in oncology · 2022Article
- International consensus recommendations on key outcome measures for organ preservation after (chemo)radiotherapy in patients with rectal cancer.Nature reviews. Clinical oncology · 2021Review
- Comparative analysis of modified Bacon operation and double stapler operation in the treatment of rectal cancer.American journal of translational research · 2021Article
- Refusal of colorectal cancer surgery in the United States: Predictors and associated cancer-specific mortality in a Surveillance, Epidemiology, and End Results (SEER) cohort.Surgery open science · 2020Article
- Changes in surgical therapies for rectal cancer over the past 100 years: A review.Annals of gastroenterological surgery · 2020Review
- Endoscopic full-thickness resection of early colorectal neoplasms using an endoscopic submucosal dissection knife: a retrospective multicenter study.Endoscopy international open · 2020Article
- Report from the 20th annual Western Canadian Gastrointestinal Cancer Consensus Conference; Saskatoon, Saskatchewan; 28-29 September 2018.Current oncology (Toronto, Ont.) · 2019Article
- Role of magnetic resonance imaging in organ-preserving strategies for the management of patients with rectal cancer.Insights into imaging · 2019Review
- Does total regression of primary rectal cancer after preoperative chemoradiotherapy represent "no tumor" status?Annals of surgical treatment and research · 2019Article
- Improved perioperative care is associated with improved long-term survival in colorectal cancer.International journal of colorectal disease · 2018Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe last three decades have witnessed significant improvements in the diagnosis, staging and treatment of rectal cancer leading to a more tailored approach. One of the most clinically relevant advances in this field is represented by transanal endoscopic microsurgery (TEM). Several studies have investigated its role in the treatment of rectal cancer. However, evidence-based recommendations are limited. The aim of this report is to provide an evidence-based review of current indications, controversies and future perspectives of TEM in the management of rectal cancer.
methodsA review of the literature has been performed in PubMed/Medline electronic databases and the Cochrane Library. Quality of evidence was evaluated according to the GRADE system.
resultsTEM allows to perform a more accurate en bloc full-thickness local excision of rectal tumors than transanal excision. TEM alone seems to provide similar oncologic results in selected T1sm1 N0 rectal cancers to those achieved by rectal resection and total mesorectal excision (TME), without impairing anorectal function. The oncologic outcomes of neoadjuvant therapy followed by TEM for selected T2 N0 rectal cancers are promising, but this approach is still under evaluation. A word of caution comes from the increased rate of suture dehiscence and rectal pain after TEM. TEM is a promising tool for the surgical treatment of locally advanced rectal cancer as a platform for transanal TME.
conclusionsSelected T1 rectal cancers with favorable features may be effectively treated with TEM without jeopardizing long-term oncologic outcomes. The lack of adequate lymphadenectomy represents the main concern of this approach for the treatment of rectal cancer. Several approaches are under evaluation to overcome this limitation.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.