Evidence map›Paper›PMID 26902320›Full record

ArticleScientific reports2016

Transient increase of interleukin-1β after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid signaling.

Bo Feng, Yangshun Tang, Bin Chen, Cenglin Xu, Yi Wang, Yunjian Dai, Dengchang Wu, Junmin Zhu, Shuang Wang, Yudong Zhou and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
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  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Interleukins in Epilepsy: Friend or Foe.Neuroscience bulletin · 2024
    Review
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  13. Article
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  16. Review
  17. Review
  18. Review
  19. Increased Excitatory Synaptic Transmission Associated with Adult Seizure Vulnerability Induced by Early-Life Inflammation in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Bo FengDepartment of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Zhejiang University, 310058, China.
Yangshun TangDepartment of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Zhejiang University, 310058, China.
Bin ChenDepartment of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Zhejiang University, 310058, China.
Cenglin XuDepartment of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Zhejiang University, 310058, China.
Yi WangDepartment of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Zhejiang University, 310058, China.
Yunjian DaiDepartment of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Zhejiang University, 310058, China.
Dengchang WuDepartment of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Zhejiang University, 310058, China.
Junmin ZhuEpilepsy Center, Department of Neurology, Second Affiliated Hospital, Zhejiang University, China.
Shuang WangEpilepsy Center, Department of Neurology, Second Affiliated Hospital, Zhejiang University, China.
Yudong ZhouDepartment of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Zhejiang University, 310058, China.
Liyun ShiDepartment of Basic Medical Science, Hangzhou Normal University, Hangzhou, China.
Weiwei HuDepartment of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Zhejiang University, 310058, China.
Xia ZhangUniversity of Ottawa Institute of Mental Health Research at the Royal, Department of Psychiatry, and Department of Cellular and Molecular Medicine, Ottawa K1Z 7K4, Canada.
Zhong ChenDepartment of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Zhejiang University, 310058, China.
Zhejiang University · CNSecond Affiliated Hospital of Zhejiang University · CNHangzhou Normal University · CNRoyal Ottawa Mental Health Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It remains unclear how infantile febrile seizures (FS) enhance adult seizure susceptibility. Here we showed that the transient increase of interleukin-1β (IL-1β) after prolonged FS promoted adult seizure susceptibility, which was blocked by interleukin-1 receptor antagonist (IL-1Ra) within a critical time window. Postnatal administered IL-1β alone mimicked the effect of FS on adult seizure susceptibility. IL-1R1 knockout mice were not susceptible to adult seizure after prolonged FS or IL-1β treatment. Prolonged FS or early-life IL-1β treatment increased the expression of cannabinoid type 1 receptor (CB1R) for over 50 days, which was blocked by IL-1Ra or was absent in IL-1R1 knockout mice. CB1R antagonist, knockdown and endocannabinoid synthesis inhibitor abolished FS or IL-1β-enhanced seizure susceptibility. Thus, this work identifies a pathogenic role of postnatal IL-1β/IL-1R1 pathway and subsequent prolonged prominent increase of endocannabinoid signaling in adult seizure susceptibility following prolonged FS, and highlights IL-1R1 as a potential therapeutic target for preventing the development of epilepsy after infantile FS.

Indexed as

AgingAnimalsBenzoxazinesCannabinoid Receptor AntagonistsCyclohexanonesGene Expression RegulationHippocampusHumansInterleukin-1betaInterleukin 1 Receptor Antagonist ProteinLipoprotein LipaseMiceMice, KnockoutMorpholinesNaphthalenesPiperidines1,6-bis(cyclohexyloximinocarbonyl)hexane(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanoneBenzoxazinesCannabinoid Receptor AntagonistsCyclohexanonesIL1B protein, mouseIl1rn protein, mouseInterleukin-1betaInterleukin 1 Receptor Antagonist ProteinLipoprotein LipaseMorpholinesNaphthalenesPiperidinesPyrazolesReceptor, Cannabinoid, CB1RimonabantRNA, Small Interfering

Identifiers

PMID26902320
PMCPMC4763292
OpenAlexW2410543800

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.