Evidence map›Paper›PMID 26902138›Full record

Observational studyHPB : the official journal of the International Hepato Pancreato Biliary Association2016

Long-term survival in laparoscopic vs open resection for colorectal liver metastases: inverse probability of treatment weighting using propensity scores.

Joel W Lewin, Nicholas A O'Rourke, Adrian K H Chiow, Richard Bryant, Ian Martin, Leslie K Nathanson, David J Cavallucci

Abstract readComparative StudyMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  13. Perioperative changes in hemoglobin levels during major hepatopancreatic surgery in transfused and non-transfused patients.Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society · 2021
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  17. [Laparoscopic vs. open resection of colorectal liver metastases].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2019
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  19. [Laparoscopic vs. open resection of colorectal liver metastases].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2018
    Article
  20. [Laparoscopic liver resection].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joel W LewinHepato-Pancreato-Biliary Surgery, Royal Brisbane & Women's Hospital, Australia. Electronic address: joel.lewin@uqconnect.edu.au.
Nicholas A O'RourkeHepato-Pancreato-Biliary Surgery, Royal Brisbane & Women's Hospital, Australia; General Surgery, The Wesley Hospital, Australia.
Adrian K H ChiowHepato-Pancreato-Biliary Surgery, Royal Brisbane & Women's Hospital, Australia.
Richard BryantHepato-Pancreato-Biliary Surgery, Royal Brisbane & Women's Hospital, Australia; General Surgery, Holy Spirit Northside Hospital, Australia.
Ian MartinGeneral Surgery, The Wesley Hospital, Australia.
Leslie K NathansonGeneral Surgery, The Wesley Hospital, Australia; General Surgery, Holy Spirit Northside Hospital, Australia.
David J CavallucciHepato-Pancreato-Biliary Surgery, Royal Brisbane & Women's Hospital, Australia; General Surgery, The Wesley Hospital, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study compares long-term outcomes between intention-to-treat laparoscopic and open approaches to colorectal liver metastases (CLM), using inverse probability of treatment weighting (IPTW) based on propensity scores to control for selection bias.

methodPatients undergoing liver resection for CLM by 5 surgeons at 3 institutions from 2000 to early 2014 were analysed. IPTW based on propensity scores were generated and used to assess the marginal treatment effect of the laparoscopic approach via a weighted Cox proportional hazards model.

resultsA total of 298 operations were performed in 256 patients. 7 patients with planned two-stage resections were excluded leaving 284 operations in 249 patients for analysis. After IPTW, the population was well balanced. With a median follow up of 36 months, 5-year overall survival (OS) and recurrence-free survival (RFS) for the cohort were 59% and 38%. 146 laparoscopic procedures were performed in 140 patients, with weighted 5-year OS and RFS of 54% and 36% respectively. In the open group, 138 procedures were performed in 122 patients, with a weighted 5-year OS and RFS of 63% and 38% respectively. There was no significant difference between the two groups in terms of OS or RFS.

conclusionIn the Brisbane experience, after accounting for bias in treatment assignment, long term survival after LLR for CLM is equivalent to outcomes in open surgery.

Indexed as

LaparoscopyColorectal NeoplasmsDisease-Free SurvivalFemaleHepatectomyHumansIntention to Treat AnalysisKaplan-Meier EstimateLiver NeoplasmsLogistic ModelsMaleMetastasectomyMiddle AgedPropensity ScoreProportional Hazards ModelsQueensland

Identifiers

PMID26902138
PMCPMC4814613

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.